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HIV and co-infections

Section edited by Carlo Torti 

This section aims to publish studies looking at all aspects of the prevention, diagnosis and management of HIV and HIV-associated infections in humans, as well as related molecular genetics, pathophysiology, and epidemiology. This section also aims to publish studies on the adverse events of HAART and non HIV-related comorbidities in the HAART era.

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  1. Content type: Research article

    Tuberculosis (TB) is the leading cause of death for individuals infected with Human immunodeficiency virus (HIV). Conversely, HIV is the most important risk factor in the progression of TB from the latent to t...

    Authors: Augustus Aturinde, Mahdi Farnaghi, Petter Pilesjö and Ali Mansourian

    Citation: BMC Infectious Diseases 2019 19:612

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  2. Content type: Research article

    Second-line Antiretroviral Therapy (ART) regimens are used when patients develop treatment failure for first-line drug regimens. It is costly unaffordable and it is not widely available for patients in resourc...

    Authors: Muluneh Alene, Tadesse Awoke, Melaku Kindie Yenit and Adino Tesfahun Tsegaye

    Citation: BMC Infectious Diseases 2019 19:599

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  3. Content type: Research article

    People aging with HIV can experience a variety of health challenges associated with HIV and multimorbidity, referred to as ‘disability’. Our aim was to characterize the disability experience and examine relati...

    Authors: Kelly K. O’Brien, Steven Hanna, Patricia Solomon, Catherine Worthington, Francisco Ibáñez-Carrasco, Soo Chan Carusone, Stephanie Nixon, Brenda Merritt, Jacqueline Gahagan, Larry Baxter, Patriic Gayle, Greg Robinson, Rosalind Baltzer Turje, Stephen Tattle and Tammy Yates

    Citation: BMC Infectious Diseases 2019 19:594

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  4. Content type: Case report

    HIV controllers (HICs) are a rare group of HIV-1-infected individuals able to naturally control viral replication. Several studies have identified the occurrence of HIV dual infections in seropositive individu...

    Authors: Diogo Gama Caetano, Fernanda Heloise Côrtes, Gonzalo Bello, Suwellen Sardinha Dias de Azevedo, Brenda Hoagland, Larissa Melo Villela, Beatriz Grinsztejn, Valdiléa Gonçalves Veloso, Monick Lindenmeyer Guimarães and Mariza Gonçalves Morgado

    Citation: BMC Infectious Diseases 2019 19:588

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  5. Content type: Research article

    Human leukocyte antigen (HLA) alleles are implicated in drug-induced hypersensitivity, including by nevirapine and abacavir. The purpose of this meta-analysis was to evaluate the relationship between HLA polym...

    Authors: Kun Hu, Qian Xiang, Zhe Wang, Guang-yan Mu, Zhuo Zhang, Ling-yue Ma, Qiu-fen Xie, Shu-qing Chen, Shuang Zhou, Xiao-dan Zhang and Yi-min Cui

    Citation: BMC Infectious Diseases 2019 19:583

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  6. Content type: Research article

    To evaluate the trends in AIDS detection and the AIDS-attributed death rate in Brazil between 2007 and 2015 and to determine the population characteristics associated with AIDS detection.

    Authors: Gerson Fernando Mendes Pereira, Meritxell Sabidó, Alessandro Caruso and Adele Schwartz Benzaken

    Citation: BMC Infectious Diseases 2019 19:579

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  7. Content type: Research article

    Antiretroviral therapy (ART) was rolled-out in Ethiopia in 2005, but there are no reports on outcome of ART and human immunodeficiency virus drug resistance (HIVDR) at national level. We described acquired dru...

    Authors: Nigus Fikrie Telele, Amare Worku Kalu, Solomon Gebre-Selassie, Daniel Fekade, Gaetano Marrone, Sebastian Grossmann, Ujjwal Neogi, Belete Tegbaru and Anders Sönnerborg

    Citation: BMC Infectious Diseases 2019 19:569

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  8. Content type: Research article

    To infer transmission direction of a HIV transmission chain is helpful not only in legal jurisdiction but also in precise intervention to prevent HIV spread. Recently, the direction of transmission is inferred...

    Authors: Jianjun Wu, Zhongwang Hu, Hui Yao, Hai Wang, Yanhua Lei, Ping Zhong, Yi Feng, Hui Xing, Yuelan Shen, Lin Jin, Aiwen Liu, Yizu Qin, Lifeng Miao, Bin Su, Yibo Zhang and Hongxiong Guo

    Citation: BMC Infectious Diseases 2019 19:566

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  9. Content type: Research article

    The proportion of older HIV-1 infected people in China has increased rapidly in recent years. Elucidation of the transmission characteristics of this high-risk population subgroup is helpful for the developmen...

    Authors: Jianjun Wu, Yu Zhang, Yuelan Shen, Xiaolin Wang, Hui Xing, Xiaohui Yang, Xinping Ding, Bing Hu, Hanping Li, Jingwan Han, Jingyun Li, Bin Su, Yongjian Liu and Lin Li

    Citation: BMC Infectious Diseases 2019 19:562

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  10. Content type: Research article

    Amphotericin-induced phlebitis is a common infusion-related reaction in patients managed for cryptococcal meningitis. High-quality nursing care is critical component to successful cryptococcosis treatment. We ...

    Authors: Cynthia Ahimbisibwe, Richard Kwizera, Jane Frances Ndyetukira, Florence Kugonza, Alisat Sadiq, Kathy Huppler Hullsiek, Darlisha A. Williams, Joshua Rhein, David R. Boulware and David B. Meya

    Citation: BMC Infectious Diseases 2019 19:558

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  11. Content type: Research article

    Among people living with HIV (PLWH), the prevalence of non-HIV related co-morbidities is increasing. Aim of the present study is to describe co-morbidity and multi-morbidity, their clustering mode and the pote...

    Authors: Paolo Maggi, Carmen R. Santoro, Marco Nofri, Elena Ricci, Nicolò De Gennaro, Chiara Bellacosa, Elisabetta Schiaroli, Giancarlo Orofino, Barbara Menzaghi, Antonio Di Biagio, Nicola Squillace, Daniela Francisci, Francesca Vichi, Chiara Molteni, Paolo Bonfanti, Giovanni Battista Gaeta…

    Citation: BMC Infectious Diseases 2019 19:555

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  12. Content type: Research article

    Late presentation to HIV/AIDS care which is attended by problems like, poor treatment outcomes, early development of opportunistic infections, increased healthcare costs, and mortality is a major problem in Et...

    Authors: Getaneh Mulualem Belay, Aklilu Endalamaw and Amare Demsie Ayele

    Citation: BMC Infectious Diseases 2019 19:534

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  13. Content type: Case report

    Tuberculosis (TB)-associated Immune reconstitution inflammatory syndrome (TB-IRIS) is an aberrant inflammatory response in TB patients with advanced human immunodeficiency virus coinfection, after antiretrovir...

    Authors: Gopalan Narendran, Deivide Oliveira-de-Souza, Caian L. Vinhaes, Kevan Akrami, Kiyoshi F. Fukutani, Kesavamurthy Banu, Padmapriyadarsini Chandrasekaran, Narayanan Ravichandran, Irini Sereti, Soumya Swaminathan and Bruno B. Andrade

    Citation: BMC Infectious Diseases 2019 19:529

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  14. Content type: Research article

    Several factors have been identified as being associated with increased adherence to antiretroviral therapy, including sero-status disclosure; however, studies examining the effect of disclosure on ART adheren...

    Authors: Getenet Dessie, Fasil Wagnew, Henok Mulugeta, Dessalegn Amare, Dube Jara, Cheru Tesema Leshargie, Ayenew Negesse, Swati Rayasam and Sahai Burrowes

    Citation: BMC Infectious Diseases 2019 19:528

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  15. Content type: Case report

    As technology progresses, several highly sensitive human immunodeficiency virus (HIV) screening kits are being researched and developed to quickly and efficiently identify serum HIV antibodies within the non-w...

    Authors: Shuangquan Yan, Jing Huang, Qiaofei Zheng, Hongguo Zhu, Zhuolin Gao, Jiaxi Feng and Youzu Xu

    Citation: BMC Infectious Diseases 2019 19:525

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  16. Content type: Research article

    Heterosexual transmission is the main driver of the HIV epidemic in Tanzania. Only one estimate of the incidence rate of intra-marital HIV seroconversion in Tanzania has been reported and was derived from data...

    Authors: Soledad Colombe, James Beard, Baltazar Mtenga, Peter Lutonja, Julius Mngara, Claudia J. de Dood, Govert J. van Dam, Paul L. A. M. Corstjens, Samuel Kalluvya, Mark Urassa, Jim Todd and Jennifer A. Downs

    Citation: BMC Infectious Diseases 2019 19:518

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  17. Content type: Research article

    Although Option B+ may be more costly than Options B, it may provide additional health benefits that are currently unclear in Yunnan province. We created deterministic models to estimate the cost-effectiveness...

    Authors: Xiaowen Wang, Guangping Guo, Jiarui Zheng and Lin Lu

    Citation: BMC Infectious Diseases 2019 19:517

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  18. Content type: Research article

    Most of studies on the relationship between drug use and HIV have focused largely on people who inject drugs. Non-injecting drug use is much more common than injecting drug use, and although it can also predis...

    Authors: Sovannary Tuot, Gitau Mburu, Phalkun Mun, Pheak Chhoun, Navy Chann, Kiesha Prem and Siyan Yi

    Citation: BMC Infectious Diseases 2019 19:515

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  19. Content type: Research article

    Regardless of chronic treatment with antiretroviral therapy (ART), the switching rate for ART regarding anchor drugs has not been articulated in real-world clinical-settings in Japan. We assessed switch rates ...

    Authors: Daniel J. Ruzicka, Naho Kuroishi, Nobuyuki Oshima, Ryuta Sakuma and Toshio Naito

    Citation: BMC Infectious Diseases 2019 19:505

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  20. Content type: Research article

    Fine scale geospatial analysis of HIV infection patterns can be used to facilitate geographically targeted interventions. Our objective was to use the geospatial technology to map age and time standardized HIV...

    Authors: Gita Ramjee, Benn Sartorius, Natashia Morris, Handan Wand, Tarylee Reddy, Justin D. Yssel and Frank Tanser

    Citation: BMC Infectious Diseases 2019 19:500

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  21. Content type: Research article

    HIV testing serves as a critical gateway for linkage and retention to care services, particularly in sub-Saharan African countries with high burden of HIV infections. However, the current progress towards addr...

    Authors: Mbuzeleni Hlongwa, Tivani Mashamba-Thompson, Sizwe Makhunga and Khumbulani Hlongwana

    Citation: BMC Infectious Diseases 2019 19:496

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  22. Content type: Research article

    A high proportion of men who have sex with men (MSM) use geosocial networking apps (Apps) to seek partners. However, the relationship of app use with HIV risk is unknown. Further, the risks of some sexually tr...

    Authors: Ning Zhao, Katherine T. Li, Yang-yang Gao, Jun-jie Xu and De-Sheng Huang

    Citation: BMC Infectious Diseases 2019 19:494

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  23. Content type: Research article

    Network meta-analyses (NMAs) provide comparative treatment effects estimates in the absence of head-to-head randomized controlled trials (RCTs). This NMA compared the efficacy and safety of dolutegravir (DTG) ...

    Authors: Sonya J. Snedecor, Matthew Radford, David Kratochvil, Richard Grove and Yogesh S. Punekar

    Citation: BMC Infectious Diseases 2019 19:484

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  24. Content type: Research article

    The HIV epidemic remains a concern on the global health agenda, despite progress made in reducing incidence. Investigation of trends among young people is important for monitoring HIV incidence and informing p...

    Authors: Chola Nakazwe, Charles Michelo, Ingvild F. Sandøy and Knut Fylkesnes

    Citation: BMC Infectious Diseases 2019 19:432

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  25. Content type: Research article

    Human immunodeficiency virus (HIV) infected children represent a very vulnerable population for anti-retroviral therapy (ART) drug resistance. As a global target, 90% of patients receiving ART should have HIV-...

    Authors: Melashu Balew Shiferaw, Demeke Endalamaw, Mulat Hussien, Manamnot Agegne, Desalegn Amare, Fikirte Estifanos and Dinbere Temesgen

    Citation: BMC Infectious Diseases 2019 19:419

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  26. Content type: Research article

    Tuberculosis (TB) and HIV makeup a deadly synergy of infectious disease, and the combined effect is apparent in resource limited countries like Ethiopia. Previous studies have demonstrated inconsistent results...

    Authors: Demeke Geremew, Aklilu Endalamaw, Markos Negash, Setegn Eshetie and Belay Tessema

    Citation: BMC Infectious Diseases 2019 19:405

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  27. Content type: Research article

    France is the European country with the lowest level of confidence in vaccines. Measurement of patients’ acceptability towards a future therapeutic HIV vaccine is critically important. Thus, the aim of this st...

    Authors: Svetlane Dimi, David Zucman, Olivier Chassany, Christophe Lalanne, Thierry Prazuck, Emmanuel Mortier, Catherine Majerholc, Isabelle Aubin-Auger, Pierre Verger and Martin Duracinsky

    Citation: BMC Infectious Diseases 2019 19:401

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  28. Content type: Research article

    Uptake of Human Immunodeficiency Virus (HIV) re-testing among postnatal mothers who had previously tested HIV-negative is crucial for the detection of recent seroconverters who are likely to have high plasma v...

    Authors: Saumu Iddy Nungu, Janneth Maridadi Mghamba, Susan Fred Rumisha and Innocent Antony Semali

    Citation: BMC Infectious Diseases 2019 19:398

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  29. Content type: Research article

    Most studies assessing drug resistant tuberculosis (DRTB) in human immunodeficiency virus (HIV) co-infected patients in India have used conventional culture- based systems to diagnose DRTB that have a longer t...

    Authors: Neil Saldanha, Kiran Runwal, Charulata Ghanekar, Sunil Gaikwad, Shrivallabh Sane and Sanjay Pujari

    Citation: BMC Infectious Diseases 2019 19:391

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  30. Content type: Research article

    Blood transfusion is one of the routine therapeutic interventions in hospitals that can be lifesaving. However, this intervention is related to several transfusion-related infections. The human immunodeficienc...

    Authors: Henok Mulugeta, Getenet Dessie, Fasil Wagnew, Dube Jara, Cheru Tesema Leshargie and Ayenew Negesse

    Citation: BMC Infectious Diseases 2019 19:383

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  31. Content type: Research article

    Antiretroviral therapy (ART) has significantly decreased HIV/AIDS-related morbidity and mortality. However, globally, many people living with HIV die from non-AIDS related illnesses including liver diseases wh...

    Authors: Faustina Pappoe, Charles Kofi Oheneba Hagan, Dorcas Obiri-Yeboah and Paul Nsiah

    Citation: BMC Infectious Diseases 2019 19:380

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  32. Content type: Research article

    Treatments for Hepatitis C virus (HCV) infection have vastly improved over the past few decades with current regimens now offering pangenotypic activity with excellent cure rates reported in clinical trials, i...

    Authors: A. Maughan, K. Sadigh, V. Angulo-Diaz, C. Mandimika, M. Villanueva, J. K. Lim and O. Ogbuagu

    Citation: BMC Infectious Diseases 2019 19:378

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  33. Content type: Research article

    Body mass index (BMI) may contribute somewhat to drug metabolism, and thus affecting the efficacy of highly active antiretroviral therapy (HAART). This study aimed to determine the frequencies of underweight, ...

    Authors: Xiaolin Li, Haibo Ding, Wenqing Geng, Jing Liu, Yongjun Jiang, Junjie Xu, Zining Zhang and Hong Shang

    Citation: BMC Infectious Diseases 2019 19:373

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  34. Content type: Study protocol

    The Joint United Nations Programme on HIV/AIDS 90–90-90 goal envisions 90% of all people receiving antiretroviral therapy to be virally suppressed by 2020. Implied in that goal is that viral load be quantified...

    Authors: Seema T. Meloni, Oche Agbaji, Charlotte A. Chang, Patricia Agaba, Godwin Imade, Stephen Oguche, Ahmed Mukhtar, Kiren Mitruka, Mackenzie Hurlston Cox, Aaron Zee and Phyllis Kanki

    Citation: BMC Infectious Diseases 2019 19:368

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  35. Content type: Research article

    Pro-inflammatory cytokines expressed in human immune deficiency virus (HIV) infection, may induce oxidative stress likely to compromise the patency of the airways or damage the lung tissues/cardiac function. H...

    Authors: S. C. Ibeneme, C. Omeje, H. Myezwa, Salome Nwaelom Ezeofor, E. M. Anieto, F. Irem, Amaka Obiageli Nnamani, Fortune Elochukwu Ezenwankwo and G. C. Ibeneme

    Citation: BMC Infectious Diseases 2019 19:359

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  36. Content type: Research article

    The geographical distribution of intestinal parasites with conditions of poverty in most countries of sub-Saharan Africa coincides with that of HIV/AIDS. However, there is paucity of studies investigating the ...

    Authors: Tuom Gebrewahid, Gebretsadkan Gebrekirstos, Mebrahtu Teweldemedhin, Hailay Gebreyesus, Abrham Awala and Kiros Tadla

    Citation: BMC Infectious Diseases 2019 19:350

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  37. Content type: Research article

    Past studies have found a relationship between detectable HIV viral load and non-communicable diseases (NCDs) in HIV-infected individuals on antiretroviral therapy in high-income settings, however there is lit...

    Authors: S. George, N. McGrath and T. Oni

    Citation: BMC Infectious Diseases 2019 19:348

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  38. Content type: Research article

    Compromised immune function, associated with human immune deficiency virus(HIV) infection, is improved by antiretroviral therapy(ART) which also decreases bone mineral density(BMD), and possibly the quality of...

    Authors: Sam Chidi Ibeneme, Franklin Onyedinma Irem, Nneka Ifeyinwa Iloanusi, Amarachi Destiny Ezuma, Fortune Elochukwu Ezenwankwo, Philip Chinedu Okere, Amaka Obiageli Nnamani, Salome Nwaelom Ezeofor, Ngozi Regina Dim and Gerhard Fortwengel

    Citation: BMC Infectious Diseases 2019 19:340

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  39. Content type: Research article

    The identification and management of cardiovascular risk factors became a major clinical issue among HIV-infected individuals in the post-cART era. As in the past decades the link between acute infections and ...

    Authors: Emersom Cicilini Mesquita, Lara Esteves Coelho, Rodrigo Teixeira Amancio, Valdilea Veloso, Beatriz Grinsztejn, Paula Luz and Fernando Augusto Bozza

    Citation: BMC Infectious Diseases 2019 19:319

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  40. Content type: Research article

    Genetic variability and liability to develop drug-resistant mutations are the main characteristics of HIV-1, which can not only increase the risk of antiretroviral treatment (ART) failure, but also can lead to...

    Authors: Zhenyan Wang, Min Zhang, Renfang Zhang, Li Liu, Yinzhong Shen, Jiangrong Wang and Hongzhou Lu

    Citation: BMC Infectious Diseases 2019 19:313

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  41. Content type: Research article

    Currently, there is limited evidence on the effectiveness of second-line antiretroviral therapy (ART) in sub-Saharan Africa. To address this challenge, outcomes of second-line protease inhibitor (PI) based ART...

    Authors: Sabin Nsanzimana, Muhammed Semakula, Vedaste Ndahindwa, Eric Remera, Dieudonne Sebuhoro, Jean Paul Uwizihiwe, Nathan Ford, Marcel Tanner, Steve Kanters, Edward J. Mills and Heiner C. Bucher

    Citation: BMC Infectious Diseases 2019 19:312

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  42. Content type: Research article

    African, Caribbean, and Black (Black) men account for 16.5% of new HIV diagnoses among men in Ontario. There is substantial evidence that sexually transmitted infections (STIs) are associated with increased li...

    Authors: LaRon E. Nelson, Wangari Tharao, Winston Husbands, Ting Sa, Nanhua Zhang, Sameer Kushwaha, David Absalom and Rupert Kaul

    Citation: BMC Infectious Diseases 2019 19:294

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  43. Content type: Research article

    The World Health Organisation approved boosted atazanavir as a preferred second line protease inhibitor in 2010. This is as an alternative to the current boosted lopinavir. Atazanavir has a lower genetic barri...

    Authors: Eva Agnes Odongpiny Laker, Maria Sarah Nabaggala, Arvind Kaimal, Damalie Nalwanga, Barbara Castelnuovo, Abdu Musubire, Agnes Kiragga, Mohammed Lamorde and Rosalind Parkes- Ratanshi

    Citation: BMC Infectious Diseases 2019 19:280

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  44. Content type: Research article

    HIV pre-exposure prophylaxis (PrEP) was implemented in France in November 2015 based on individual-level risk factors for HIV infection. We evaluated the proportion of missed opportunities for PrEP among newly...

    Authors: C. Lions, O. Cabras, L. Cotte, T. Huleux, A. Gagneux-Brugnon, A. Makinson, A. Cabié, B. Bonnet, C. Duvivier, L. Hocqueloux, E. Cua, A. Cheret, L. Hustache-Mathieu, V. Obry-Roguet, C. Jacomet and I. Poizot-Martin

    Citation: BMC Infectious Diseases 2019 19:278

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  45. Content type: Research article

    Tuberculosis (TB) is a major cause of death in HIV patients worldwide. Here we describe the epidemiology and outcome of HIV-TB co-infections in a high-income country with low TB incidence and integrated HIV an...

    Authors: Ville Holmberg, Hanna Soini, Pia Kivelä, Jukka Ollgren and Matti Ristola

    Citation: BMC Infectious Diseases 2019 19:264

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  46. Content type: Research article

    The WHO guidelines for the management of advanced HIV disease recommend a package of care consisting of rapid initiation of antiretroviral therapy (ART), enhanced screening and diagnosis of tuberculosis (TB) a...

    Authors: Noelle A. Benzekri, Jacques F. Sambou, Sanou Ndong, Ibrahima Tito Tamba, Dominique Faye, Mouhamadou Baïla Diallo, Jean Phillippe Diatta, Khadim Faye, Ibrahima Sall, Fatima Sall, Noël Magloire Manga, Jean Jacques Malomar, Cheikh T. Ndour, Stephen E. Hawes, Moussa Seydi and Geoffrey S. Gottlieb

    Citation: BMC Infectious Diseases 2019 19:261

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  47. Content type: Research article

    The effect of ART initiation time on HIV-1 DNA reservoir in chronically infected individuals is not well understood. Determining the potential influencing factors associated with a low HIV-1 DNA level in chron...

    Authors: Ling Luo, Nidan Wang, Yongsong Yue, Yang Han, Wei Lv, Zhengyin Liu, Zhifeng Qiu, Hongzhou Lu, Xiaoping Tang, Tong Zhang, Min Zhao, Yun He, He Shenghua, Min Wang, Yongzhen Li, Shaobiao Huang…

    Citation: BMC Infectious Diseases 2019 19:257

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  48. Content type: Research article

    Tuberculosis and diabetes mellitus are significant global public health challenges. In Sub-Saharan Africa, study findings regarding prevalence of diabetes mellitus amongst tuberculosis patients have been incon...

    Authors: Animut Alebel, Amsalu Taye Wondemagegn, Cheru Tesema, Getiye Dejenu Kibret, Fasil Wagnew, Pammla Petrucka, Amit Arora, Amare Demsie Ayele, Mulunesh Alemayehu and Setegn Eshetie

    Citation: BMC Infectious Diseases 2019 19:254

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  49. Content type: Research article

    Evidence on patient-reported outcomes of newly diagnosed HIV patients is scarce, and largely cross-sectional. This prospective cohort study describes the prevalence of, and changes in, patient-reported outcome...

    Authors: Victoria Simms, Julia Downing, Eve Namisango, R. Anthony Powell, Faith Mwangi-Powell, Irene J. Higginson and Richard Harding

    Citation: BMC Infectious Diseases 2019 19:248

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