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Bacterial and fungal diseases

Section edited by Ivan FN Hung, Jorge Garbino and Kelvin To

This section aims to publish studies looking at all aspects of the prevention, diagnosis and management of bacterial and fungal diseases in humans, as well as related molecular genetics, pathophysiology, and epidemiology. This section includes studies relating to antibiotic resistance and healthcare-associated infections.

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  1. Content type: Research article

    Cervicofacial necrotizing fasciitis (NF) is a rare life-threatening infection in the head and neck region that characteristically spreads along the fascial planes to involve subcutaneous tissues, fascia and fa...

    Authors: Arnold A. Mtenga, Boniphace M. Kalyanyama, Sira S. Owibingire, Karpal S. Sohal and Elison N.M. Simon

    Citation: BMC Infectious Diseases 2019 19:642

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  2. Content type: Research article

    The outcomes of deep-seated abscesses attributed to chronic disseminated candidiasis (CDC) in patients with hematological malignancies have rarely been reported in recent years.

    Authors: Chien-Yuan Chen, Aristine Cheng, Feng-Ming Tien, Po-Chu Lee, Hwei-Fang Tien, Wang-Huei Sheng and Yee-Chun Chen

    Citation: BMC Infectious Diseases 2019 19:635

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  3. Content type: Study protocol

    Group A Streptococcal (GAS) infections cause the autoimmune disease acute rheumatic fever (ARF), which can progress to chronic rheumatic heart disease (RHD). Treating pharyngitis caused by GAS with antibiotics...

    Authors: Julie Bennett, Nicole J. Moreland, Jane Oliver, Julian Crane, Deborah A. Williamson, Dianne Sika-Paotonu, Matire Harwood, Arlo Upton, Susan Smith, Jonathan Carapetis and Michael G. Baker

    Citation: BMC Infectious Diseases 2019 19:633

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  4. Content type: Research article

    In hospitalised patients with diarrhoea a positive campylobacter stool Polymerase Chain Reaction (PCR) test with negative culture results as well as Enteropathogenic Escherichia coli (EPEC) positive stool PCRs, c...

    Authors: Jan-Erik Berdal, Benoit Follin-Arbelet and Jørgen Vildershøj Bjørnholt

    Citation: BMC Infectious Diseases 2019 19:630

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  5. Content type: Research article

    Nosocomial infections and persistence of multidrug resistant biofilm forming Acinetobacter baumannii in hospitals has made it as a serious problem in healthcare settings worldwide.

    Authors: Habib Zeighami, Fatemeh Valadkhani, Reza Shapouri, Elham Samadi and Fakhri Haghi

    Citation: BMC Infectious Diseases 2019 19:629

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  6. Content type: Research article

    The point mutations in 23S rRNA gene of Mycoplasma pneumoniae (M. pneumoniae) can lead to high-level resistance to macrolides. This study aimed to evaluate allele-specific real-time PCR (ASPCR) to detect the resi...

    Authors: Dongxing Guo, Wenjuan Hu, Baoping Xu, Jingyi Li, Dan Li, Shaogang Li, Zhaoyong Wu, Ran Wei, Xiujun Tian, Kunling Shen and Deli Xin

    Citation: BMC Infectious Diseases 2019 19:616

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  7. Content type: Research article

    Bloodstream infections (BSI) due to Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae (KPC-Kp) have become an important problem and they are associated with a high mortality rate. The aim of our s...

    Authors: Lucia Brescini, Gianluca Morroni, Chiara Valeriani, Sefora Castelletti, Marina Mingoia, Serena Simoni, Annamaria Masucci, Roberto Montalti, Marco Vivarelli, Andrea Giacometti and Francesco Barchiesi

    Citation: BMC Infectious Diseases 2019 19:611

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  8. Content type: Research article

    Bloodstream infections (BSI) are associated with high morbidity and mortality. This scenario worsens with the emergence of drug-resistant pathogens, resulting in infections which are difficult to treat or even...

    Authors: Helena Ferreira Leal, Jailton Azevedo, Giulyana Evelyn Oliveira Silva, Angelica Maria Lima Amorim, Larissa Rangel Cabral de Roma, Ana Carolina Palmeira Arraes, Edilane Lins Gouveia, Mitermayer Galvão Reis, Ana Verena Mendes, Marcio de Oliveira Silva, Maria Goreth Barberino, Ianick Souto Martins and Joice Neves Reis

    Citation: BMC Infectious Diseases 2019 19:609

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  9. Content type: Research article

    Blood culture bottles (BCBs) provide a semiautomated method for culturing periprosthetic tissue specimens. A study evaluating BCBs for culturing clinical samples other than body fluids is needed before impleme...

    Authors: Adriana Sanabria, Merethe E. O. Røkeberg, Mona Johannessen, Johanna Ericson Sollid, Gunnar Skov Simonsen and Anne-Merethe Hanssen

    Citation: BMC Infectious Diseases 2019 19:607

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  10. Content type: Research article

    This study aims to investigate the pathogen distribution and drug resistance in patients with acute cerebral infarction complicated with diabetes mellitus and nosocomial pulmonary infection.

    Authors: Yu-Xin Liu, Qiu-Mei Cao and Bing-Chen Ma

    Citation: BMC Infectious Diseases 2019 19:603

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  11. Content type: Research article

    Methicillin-resistant Staphylococcus aureus (MRSA) is associated with significant morbidity and mortality and has resultant important economic and societal costs underscoring the need for accurate surveillance. I...

    Authors: Frederick K. Wangai, Moses M. Masika, Marybeth C. Maritim and R. Andrew Seaton

    Citation: BMC Infectious Diseases 2019 19:596

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  12. Content type: Research article

    Antibiotic resistance is a worldwide problem that crosses international boundaries and spread between continents easily. Hence, information on the existence of the causative microorganisms and their susceptibi...

    Authors: Tsegaye Alemayehu, Mulubrahan Ali, Enkosilassie Mitiku and Mengistu Hailemariam

    Citation: BMC Infectious Diseases 2019 19:585

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  13. Content type: Study protocol

    Solid organ transplantation (SOT) is a well-established and life-saving treatment for patients with end-stage organ failure. Organ rejection and infections are among the main complications to SOT and largely d...

    Authors: Camilla Heldbjerg Drabe, Søren Schwartz Sørensen, Allan Rasmussen, Michael Perch, Finn Gustafsson, Omid Rezahosseini, Jens D. Lundgren, Sisse Rye Ostrowski and Susanne Dam Nielsen

    Citation: BMC Infectious Diseases 2019 19:573

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  14. Content type: Research article

    Carbapenemase-producing organisms (CPOs) have emerged as antibiotic-resistant bacteria of global concern. Here we assessed the performance of the Carba (beta) assay, a multiplex real-time PCR assay developed b...

    Authors: Amanda Bordin, Ella Trembizki, Madeline Windsor, Rachel Wee, Lit Yeen Tan, Cameron Buckley, Melanie Syrmis, Haakon Bergh, Kyra Cottrell, Hosam M. Zowawi, Hanna E. Sidjabat, Patrick N. A. Harris, Graeme R. Nimmo, David L. Paterson and David M. Whiley

    Citation: BMC Infectious Diseases 2019 19:571

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  15. Content type: Case report

    Kodamaea ohmeri is a yeast is frequently mistaken for Candida, which belongs to the same family. This micro-organism has been reported to cause life-threatening infections in humans.

    Authors: K. Diallo, B. Lefevre, G. Cadelis, J. C. Gallois, F. Gandon, M. Nicolas and B. Hoen

    Citation: BMC Infectious Diseases 2019 19:570

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  16. Content type: Research article

    To detect carbapenemase-producing Gram-negative bacteria in bacterial laboratories at medical settings, a new immunochromatographic assay for New Delhi metallo-β-lactamases (NDMs) was developed.

    Authors: Tatsuya Tada, Jun-ichiro Sekiguchi, Shin Watanabe, Kyoko Kuwahara-Arai, Naeko Mizutani, Izumi Yanagisawa, Tomomi Hishinuma, Khin Nyein Zan, San Mya, Htay Htay Tin and Teruo Kirikae

    Citation: BMC Infectious Diseases 2019 19:565

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  17. Content type: Research article

    Acute meningitis and encephalitis syndromes (AMES) is a severe neurological infection which causes high case fatality and severe sequelae in children. To determine the etiology of childhood AMES in Shenzhen, a...

    Authors: Hongwei Shen, Chunqing Zhu, Xiaorong Liu, Dongli Ma, Chunli Song, Lintao Zhou, Zuer Wang, Yongxuan Ou, Wen Ma, Xianghui Shi, Xuejun Ma and Yiwen Zhou

    Citation: BMC Infectious Diseases 2019 19:560

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  18. Content type: Research article

    The effectiveness of Helicobacter pylori first-line treatment has decreased drastically with the rise of strains resistant to clarithromycin. Therapy failure has also been described in patients with infections by...

    Authors: Betsy Verónica Arévalo-Jaimes, Diana F. Rojas-Rengifo, Carlos Alberto Jaramillo, Belén Mendoza de Molano, José Fernando Vera-Chamorro and María del Pilar Delgado

    Citation: BMC Infectious Diseases 2019 19:546

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  19. Content type: Research article

    Clinical microbiology laboratories are asked to process large numbers of urine specimens for culture, but only 20–40% of them are positive. Therefore, a rapid, reliable screening method is necessary to speed u...

    Authors: Jong-Mi Lee, Doo-Jin Baek, Kang Gyun Park, Eunhee Han and Yeon-Joon Park

    Citation: BMC Infectious Diseases 2019 19:531

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  20. Content type: Case report

    Infective endocarditis (IE) caused by gram-negative bacilli is rare. However, the incidence of this severe infection is rising because of the increasing number of persons at risk, such as patients with immunos...

    Authors: Nicolas Gürtler, Michael Osthoff, Florian Rueter, Daniel Wüthrich, Lukas Zimmerli, Adrian Egli and Stefano Bassetti

    Citation: BMC Infectious Diseases 2019 19:530

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  21. Content type: Research article

    A cholera outbreak started on 29 February in Bwikhonge Sub-county, Bulambuli District in Eastern Uganda. Local public health authorities implemented initial control measures. However, in late March, cases shar...

    Authors: Paul Edward Okello, Lilian Bulage, Alex Ario Riolexus, Daniel Kadobera, Benon Kwesiga, Henry Kajumbula, Muhamed Mulongo, Eunice Jennifer Namboozo, Godfrey Pimundu, Isaac Ssewanyana, Charles Kiyaga, Steven Aisu and Bao-Ping Zhu

    Citation: BMC Infectious Diseases 2019 19:516

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  22. Content type: Research article

    Monofocal necrotizing fasciitis (MONF) involves a single site in a rapidly progressing infection and necrosis of the fascia and surrounding soft tissue. Synchronous multifocal necrotizing fasciitis (SMNF), the...

    Authors: Ching-Yu Lee, Tsan-Wen Huang, Meng-Huang Wu, Tsung-Jen Huang, Yan-Rong Li, Evelyn Jou-Chen Huang and Yao-Hung Tsai

    Citation: BMC Infectious Diseases 2019 19:513

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  23. Content type: Research article

    In China multidrug-resistant bacteria pose a considerable threat to public health. Antimicrobial resistance has weakened the effectiveness of many medicines widely used today. Thus, discovering new antibacteri...

    Authors: Chunjiang Zhao, Xiaojuan Wang, Yawei Zhang, Ruobing Wang, Qi Wang, Henan Li and Hui Wang

    Citation: BMC Infectious Diseases 2019 19:508

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  24. Content type: Case report

    Scalp mycosis is often caused by dermatophytes and was so called tinea capitis. There is no published report caused by Aspergillus protuberus. We report a rare case of kerion-type scalp mycosis caused by A. protu...

    Authors: Jinjing Jia, Min Chen, Xiumei Mo, Junfeng Liu, Fenggen Yan, Zhengxiao Li, Shaoqiong Xie and Dacan Chen

    Citation: BMC Infectious Diseases 2019 19:506

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  25. Content type: Research article

    Urinary tract infection (UTI) is frequently diagnosed in the Emergency Department (ED). Staphylococcus aureus (SA) is an uncommon isolate in urine cultures (0.5–6% of positive urine cultures), except in patients ...

    Authors: Thomas Lafon, Ana Catalina Hernandez Padilla, Arthur Baisse, Lucie Lavaud, Marine Goudelin, Olivier Barraud, Thomas Daix, Bruno Francois and Philippe Vignon

    Citation: BMC Infectious Diseases 2019 19:504

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  26. Content type: Research article

    Francisella tularensis is the causative agent of tularemia in humans and a large number of animal species. Considering recent evidence of the circulation of this bacterium in different parts of Iran, especially i...

    Authors: Saber Esmaeili, Ahmad Ghasemi, Razi Naserifar, Ali Jalilian, Leila Molaeipoor, Max Maurin and Ehsan Mostafavi

    Citation: BMC Infectious Diseases 2019 19:502

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  27. Content type: Research article

    There is currently no research on the diagnostic value of metagenomic next-generation sequencing (mNGS) for a single pathogens in CSF. The aim of this study was to analyse the value of mNGS for identifying Strept...

    Authors: Xi-xi Zhang, Ling-yun Guo, Lin-lin Liu, Ao Shen, Wen-ya Feng, Wen-hua Huang, Hui-li Hu, Bing Hu, Xin Guo, Tian-ming Chen, He-ying Chen, Yong-qiang Jiang and Gang Liu

    Citation: BMC Infectious Diseases 2019 19:495

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  28. Content type: Research article

    We describe the clinical features of a cohort of patients with liver abscesses and investigate relationships between clinical, radiological and microbiological findings and mortality.

    Authors: Lorna Neill, Frances Edwards, Simon M. Collin, David Harrington, Dominic Wakerley, Guduru Gopal Rao and Alastair C. McGregor

    Citation: BMC Infectious Diseases 2019 19:490

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  29. Content type: Research article

    There are limited studies focusing on liver abscess with negative microbiological cultures. This study evaluated the clinical and prognostic differences of patients with culture-negative liver abscess (CNLA) c...

    Authors: Jai Hoon Yoon, Youn Jeong Kim and Sang Il Kim

    Citation: BMC Infectious Diseases 2019 19:488

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  30. Content type: Research article

    Typhoid fever remains a major public health problem in Zimbabwe with recurrent outbreaks reported since 2009. To provide guidance on appropriate treatment choice in order to minimise the morbidity and mortalit...

    Authors: Tapfumanei Mashe, Muchaneta Gudza-Mugabe, Andrew Tarupiwa, Ellen Munemo, Sekesai Mtapuri-Zinyowera, Shannon L. Smouse, Arvinda Sooka, Babill Stray-Pedersen, Anthony M. Smith and Joshua Mbanga

    Citation: BMC Infectious Diseases 2019 19:487

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  31. Content type: Research article

    The increase in drug resistance to affordable antibiotics used to treat Gram positive bacterial infections has complicated the management of enterococcal infections. Resistance to vancomycin, one of the most p...

    Authors: David P. Kateete, Moses Edolu, Edgar Kigozi, Jeffrey Kisukye, Hannington Baluku, Frank Nobert Mwiine and Christine F. Najjuka

    Citation: BMC Infectious Diseases 2019 19:486

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  32. Content type: Case report

    Bordetella trematum is an infrequent Gram-negative coccobacillus, with a reservoir, pathogenesis, a life cycle and a virulence level which has been poorly elucidated and understood. Related information is scarce ...

    Authors: Thaís Regina y Castro, Roberta Cristina Ruedas Martins, Nara Lúcia Frasson Dal Forno, Luciana Santana, Flávia Rossi, Alexandre Vargas Schwarzbold, Silvia Figueiredo Costa and Priscila de Arruda Trindade

    Citation: BMC Infectious Diseases 2019 19:485

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  33. Content type: Research article

    Staphylococcus aureus and beta-hemolytic streptococci (BHS) diseases disproportionately affect populations in middle/low-income countries. To assess if this disparity is reflected in colonization by these organis...

    Authors: Felipe Piedade Gonçalves Neves, Mariel Asbury Marlow, Gabriel Rezende-Pereira, Marcos Gabriel Pinheiro, Allyne Fandino Martinez dos Santos, Maria de Fátima Nogueira de Freitas, Rosana Rocha Barros, Fábio Aguiar-Alves, Claudete Aparecida Araújo Cardoso and Lee Woodland Riley

    Citation: BMC Infectious Diseases 2019 19:478

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  34. Content type: Case report

    Leptospirosis is one of the leading global zoonotic causes of morbidity and mortality. It is induced by a pathogenic spirochete of the genus Leptospira. The icteric form of leptospirosis is characterized by pr...

    Authors: Alicja J. Kunikowska, Monika Wildgruber, Ewert Schulte-Frohlinde, Tobias Lahmer, Roland M. Schmid and Wolfgang Huber

    Citation: BMC Infectious Diseases 2019 19:473

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  35. Content type: Case report

    Bicycle-spoke injuries rarely cause late complications of infection, including sepsis and sepsis-associated encephalopathy, with appropriate treatments.

    Authors: Ryuichi Takemoto, Yoshitomo Motomura, Noriyuki Kaku, Yuko Ichimiya, Mamoru Muraoka, Shunsuke Kanno, Tamami Tanaka, Yasunari Sakai, Yoshihiko Maehara and Shouichi Ohga

    Citation: BMC Infectious Diseases 2019 19:472

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  36. Content type: Research article

    Pulmonary computed tomography (CT) scans are commonly used as part of the clinical criteria in diagnostic workup of invasive fungal diseases like invasive aspergillosis, and may identify radiographic abnormali...

    Authors: Jie Jin, Depei Wu, Yang Liu, Sisi Pan, Jean Li Yan, Jalal A. Aram, Yin-jun Lou, Haitao Meng, Xiaochen Chen, Xian’an Zhang, Ilan S. Schwartz and Thomas F. Patterson

    Citation: BMC Infectious Diseases 2019 19:471

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  37. Content type: Research article

    Antibiotic resistance due to overuse of antimicrobials is an issue that has been of concern to many health institutions and society in general. Resistant infections have high impact in low income countries sin...

    Authors: Yohana Haile Berhe, Nebyu Daniel Amaha and Amon Solomon Ghebrenegus

    Citation: BMC Infectious Diseases 2019 19:465

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  38. Content type: Research article

    The emergence of leptospirosis-associated severe pulmonary hemorrhagic syndrome (SPHS) with high case fatality has been reported from many countries. Understanding of clinical disease and sequel of SPHS needs ...

    Authors: Nalaka Herath, Wimalasiri Uluwattage, Theshanthi Weliwitiya, Lilani Karunanayake, Sarath Lekamwasam, Neelakanthi Ratnatunga, Panduka Karunanayake, Sugeesha Wickramasinghe, Sanjitha Patabendi, Suranjith Senaviratne and Suneth Agampodi

    Citation: BMC Infectious Diseases 2019 19:451

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  39. Content type: Research article

    Brucellosis is an infectious zoonotic disease and is common especially among pastoral communities in most low and middle-income countries. The aim of this study was to determine sero-prevalence, and risk facto...

    Authors: Nuol Aywel Madut, Moses Ocan, Adrian Muwonge, John Bwalya Muma, George William Nasinyama, Jacques Godfroid, Ambrose Samuel Jubara and Clovice Kankya

    Citation: BMC Infectious Diseases 2019 19:450

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  40. Content type: Research article

    Human pathogens transmitted through environmental pathways are subject to stress and pressures outside of the host. These pressures may cause pathogen pathovars to diverge in their environmental persistence an...

    Authors: Andrew F. Brouwer, Marisa C. Eisenberg, Nancy G. Love and Joseph N.S. Eisenberg

    Citation: BMC Infectious Diseases 2019 19:449

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  41. Content type: Case report

    Pasteurella multocida (P. multocida) forms part of the normal flora of many animals. Although it is a common causative agent of skin and soft tissue infection after an animal bite or scratch, in rare cases it can...

    Authors: Koji Oh, Takafumi Inoue, Toshihiko Saito, Chihiro Nishio and Hiroki Konishi

    Citation: BMC Infectious Diseases 2019 19:448

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  42. Content type: Research article

    Helicobacter pylori (H.pylori) infection is a common medical problem in resource limited areas. The treatment outcome after triple therapy has not been well studied in developing countries and preliminary data su...

    Authors: Hyasinta Jaka, Andreas Mueller, Christa Kasang and Stephen E. Mshana

    Citation: BMC Infectious Diseases 2019 19:447

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  43. Content type: Research article

    Candidaemia is associated with high mortality. Variables associated with mortality have been published previously, but not developed into a risk predictive model for mortality. We sought to describe the curren...

    Authors: C. Keighley, S. C-A. Chen, D. Marriott, A. Pope, B. Chapman, K. Kennedy, N. Bak, N. Underwood, H. L. Wilson, K. McDonald, J. Darvall, C. Halliday, S. Kidd, Q. Nguyen, K. Hajkowicz, T. C. Sorrell…

    Citation: BMC Infectious Diseases 2019 19:445

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  44. Content type: Research article

    Brucellosis has extensive clinical spectrum, clinicians have insufficient understanding of the disease, and the misdiagnosis rate is still high. By collecting and analyzing the clinical characteristics of pati...

    Authors: Wenhui Jiang, Jiwang Chen, Qian Li, Lisheng Jiang, Yanxin Huang, Yinghua Lan and Yongguo Li

    Citation: BMC Infectious Diseases 2019 19:439

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