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Table 4 MICs of 14 antimicrobial agents for 73 TCD isolates by agar dilution method

From: Epidemiology of Clostridium difficile infection in hospitalized adults and the first isolation of C. difficile PCR ribotype 027 in central China

Antimicrobial agent Breakpoint of resistant (ug/ml) MIC (ug/ml) No. (%) of isolates
MIC50 (ug/ml) MIC90 (ug/ml) Range (ug/ml) Sensitive Intermediate Resistant
Metronidazole ≥ 32 0.25 0.25 ≤0.03–1 73 (100) 0 (0) 0 (0)
Piperacillin/tazobactam ≥128/4 4 8 ≤0.03–16 73 (100) 0 (0) 0 (0)
Meropenem ≥16 1 2 ≤0.03–8 72 (98.6) 1 (1.4) 0 (0)
Tetracycline ≥16 0.25 16 ≤0.03–32 54 (74.0) 9 (12.3) 10 (13.7)
Clindamycin ≥8 8 > 128 ≤0.03- > 128 27 (37.0) 7 (9.6) 39 (53.4)
Erythromycin ≥8 128 > 128 ≤0.03- > 128 28 (38.4) 45 (61.6)
Chloramphenicol ≥ 32 4 8 ≤0.03–16 72 (98.6) 1 (1.4) 0 (0)
Vancomycin ≥ 32 0.5 1 ≤0.03–16 73 (100) 0 (0)
Rifampicin ≥ 32 ≤0.03 ≤0.03 ≤0.03–1 73 (100) 0 (0)
Levofloxacin ≥8 4 64 ≤0.03- > 128 61 (83.6) 12 (16.4)
Ciprofloxacin ≥8 8 32 ≤0.03- > 128 21 (28.8) 52 (71.2)
Moxifloxacin ≥8 2 8 ≤0.03–32 64 (87.7) 0 (0) 9 (12.3)
Fusidic acid > 0.5 0.5 8 ≤0.03–16 40 (54.8) 33 (45.2)
Linezolid > 4 2 4 ≤0.03–4 73 (100) 0 (0)