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Table 5 Prognostic factors associated with the development of sepsis and septic shock in PLA patients

From: Comparison of clinical characteristics and outcomes of pyogenic liver abscess patients < 65 years of age versus ≥ 65 years of age

Variable (N = 332) Univariate analysis Multivariate analysis
Yes N = 154 No N = 178 P value OR (95% CI) P value
Age (years; median, range) 56(18–85) 59(20–89) 0.290   
Gender (Male/Female) 88/66 99/79 0.780   
Etiologies (n, %)
 Biliary source 53(34.1%) 54(30.3%) 0.428   
 Portal vein seeding, bowel and/or pelvic pathology 17(11.0%) 12(6.7%) 0.167   
 Hepatic artery seeding 17(11.0%) 2(1.1%) < 0.001 0.105(0.023–0.486) 0.004
 Direct extension 17(11.0%) 22(12.4%) 0.709   
 Trauma to the liver 5(3.2%) 7(3.9%) 0.738   
 Cryptogenic infection 45(29.2%) 81(45.5%) 0.002 1.406(0.824–2.397) 0.211
Comorbidities (n, %)
 Smoking 49(31.8%) 41(23.0%) 0.073   
 Drinking 33(21.4%) 23(12.9%) 0.039 0.617(0.329–1.154) 0.131
 Hypertension 28(18.2%) 41(23.0%) 0.277   
 Diabetes mellitus 56(36.4%) 50(28.1%) 0.107   
 Hepatobiliary malignant diseases 20(13.0%) 20(11.2%) 0.625   
 Cholelithiasis 58(37.7%) 65(36.5%) 0.829   
 Cirrhosis 4(2.6%) 10(5.6%) 0.170   
 Viral hepatitis 8(5.2%) 15(8.4%) 0.886   
 Coronary artery disease 5(3.2%) 10(5.6%) 0.413   
Surgery history
 Abdominal surgery history 81(52.6%) 74(41.6%) 0.045 0.617(0.368–1.035) 0.067
  Hepatobiliary surgery 67(43.5%) 62(34.8%) 0.106   
  Other surgery 14(9.1%) 12(6.7%) 0.427