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Table 4 Association between rs187084 and TB, LTBI and PTB susceptibility in Chinese Han population

From: Association of TLR8 and TLR9 polymorphisms with tuberculosis in a Chinese Han population: a case-control study

  First sample Second sample
TB, n(%) Controls, n(%) ORa (95% CI) Pa PTB, n(%) LTBI, n (%) ORb (95% CI) Pb LTBI, n(%) HC, n (%) ORb (95% CI) Pb
Genotype
 GG 75 (12.9) 74 (12.3) 1.07 (0.74–1.55) 0.70 41 (19.6) 29 (14.5) 1.80 (0.99–3.27) 0.06 29 (14.5) 30 (14.8) 0.83 (0.46–1.52) 0.55
 GA 267 (46.0) 271 (44.9) 1.06 (0.83–1.36) 0.64 93 (44.5) 71 (35.5) 1.68 (1.07–2.65) 0.03 71 (35.5) 93 (45.8) 0.64 (0.41–0.98) 0.04
 AA 238(41.0) 259 (42.9) 1 Reference 75 (35.9) 100 (50.0) 1 Reference 100 (50.0) 80 (39.4) 1 Reference
Allele
 G 417 (35.9) 419 (34.7) 1.05 (0.88–1.24) 0.6 175 (41.9) 129 (32.3) 1.48(1.10–2.00) 0.01 129 (32.3) 153 (37.7) 0.82 (0.61–1.10) 0.19
 A 743 (64.1) 789 (65.3) 1 Reference 243 (58.1) 271 (67.8) 1 Reference 271 (67.8) 253 (62.3) 1 Reference
Dominant
 GG + GA 342 (59.0) 345 (57.1) 1.07 (0.85–1.35) 0.59 134 (64.1) 100 (50.0) 1.70 (1.12–2.57) 0.01 100 (50.0) 123 (60.6) 0.68 (0.46–1.02) 0.06
 AA 238 (41.0) 259 (42.9) 1 Reference 75 (35.9) 100 (50.0) 1 Reference 100 (50.0) 80 (39.4) 1 Reference
Recessive
 GG 75 (12.9) 74 (12.3) 1.05 (0.74–1.48) 0.8 41 (19.6) 29 (14.5) 1.40 (0.81–2.42) 0.22 29 (14.5) 30 (14.8) 1.03 (0.59–1.79) 0.93
 GA + AA 505 (87.1) 530 (87.7) 1 Reference 168 (80.4) 171 (85.5) 1 Reference 171 (85.5) 173 (85.2) 1 Reference
  1. Abbreviations: TB tuberculosis, PTB pulmonary tuberculosis, LTBI latent tuberculosis infection, HC healthy control, a, adjusted for age, gender and smoking with logistic regression; b, adjusted for age and gender with logistic regression; OR, odds ratio; CI, confidence interval