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Table 5 Minimal inhibitory concentrations (MIC) for selected β-lactam antibiotics for 55 pneumococcal isolates obtained during AOM and post-treatment visits

From: Resistant Streptococcus pneumoniae strains in children with acute otitis media– high risk of persistent colonization after treatment

Antibiotics   Number of strains with MIC (mg/L) Range MIC50 MIC90
≤0.023 0.064 0.12 0.19 0.38 0.5 0.75 1.0 1.5 2 3 4 16 24 32 48 64 ≥256
Penicilin MEF AOM 4    1 1 2 4 3 1 1          0.023–2.0 0.75 2.0
NP/OP AOM 3   1 1   2 4 3 1 2          0.023–2.0 0.75 2.0
PT visit     1 2 1   4   3 1         0.19–2.0 1.0 2.0
Ampicillin MEF AOM 4    1 2   2   5 1 2         0.023–3.0 0.75 3.0
NP/OP AOM 3   1 1 2   2   4 2 2         0.023–3.0 0.75 3.0
PT visit    1   2   2 1 2 1 2 1        0.12–4.0 1.0 3.0
Cefaclor MEF AOM      4   1    1    1 2 5 1 1 1 0.38–256 24 64
NP/OP AOM      3 1    1 1    1 2 5 1   2 0.38–256 24 256
PT visit          1   1   1 2 3 1 1 2 1.5–256 32 256
Cefotaxime MEF AOM 4   1 2 1 3 4 1 1           0.023–1.5 0.5 1.0
NP/OP AOM 3 1 1 2 1 3 3 1 1 1          0.023–2.0 0.5 1.5
PT visit    1 1 1 2 4 2   1          0.12–2.0 0.75 1.0
Imipenem MEF AOM 4 2 3 3 5               0.023–0.38 0.12 0.38
NP/OP AOM 3 3 3 2 5   1             0.023–0.75 0.12 0.38
PT visit   1 4 3 2 1 1             0.064–0.75 0.19 0.5
  1. MEF middle ear fluid, nasopharyngeal (NP)/oropharyngeal (OP) samples, PT post-treatment