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Table 4 Phenotypic and genotypic characteristics of 25 pneumococcal strains isolated from children with AOM

From: Resistant Streptococcus pneumoniae strains in children with acute otitis media– high risk of persistent colonization after treatment

No of strain Serotype Antibiotic resistance pattern Site of isolation Sequence type Predicted founder ST/CCa Related PMEN clone
AOM PT visit
MEF R/L NP/OP NP/OP
1 14 PECcSxt +/+ +/− +/− 143 156/CC1 Spain 9 V-3 DLV
2 19F PTeCSxt −/+ +/− −/− 423 15/CC3 England 14–9 SLV
3 14 PECcTeSxt +/− +/− NA 156 156/CC1 Spain 9 V-3
5 14 PECcTeSxt +/− +/− +/+ 156 156/CC1 Spain 9 V-3
10 19F PECcTeCSxt −/+ +/+ −/− 87 88/CC50  
11 23F PECcTeCSxt +/+ +/− +/+ 2033 81/CC13 Spain 23F-1 SLV
14 19F PECcTeCSxt +/− −/− −/− 87 88/CC50  
22 22F S −/− −/+ −/− 433 433/CC23  
27 18C S −/+ −/− −/− 496 496/CC192  
28 23F PECcTeSxt +/+ +/+ +/− 81 81/CC13 Spain 23F-1
30 6B PECcCSxt +/+ −/− −/− 135 473/CC8  
31 14 PECcSxt +/+ −/− −/− 143 156/CC1  
33 19A PECcTeSxt −/− +/− −/+ 320 320CC2  
35A 19F PECcSxt −/+ −/− +/− 320 320/CC2  
35B 19F PECcSxt −/− +/− −/− 9062 320/CC2  
41 14 E +/− +/− −/− 9 15/CC3 England 14–9
42 15A PECcTe −/− −/+ +/− 374 63/CC10 Sweden 15A-25 SLV
44 14 PECcTe −/+ +/− +/− 10,340 156/CC1  
48A 14 PECcSxt −/− −/− +/− 10,342 88/CC50  
48B 14 PECcTeCSxt −/− −/− +/− 15 15/CC3 England 14–9 SLV
49 14 PECcTeSxt −/− +/− +/− 156 156/CC1 Spain 9 V-3
55 14 PECcSxt −/+ +/− +/− 15 15/CC3 England 14–9 SLV
56 6B PECcTeCSxt −/− +/− −/− 135 473/CC8  
60 3 S +/+ +/− −/− 505 180/CC16  
62 19F TeCSxt +/+ −/− −/− 423 15/CC3 England 14–9 SLV
  1. MEF middle ear fluid, right (R)/left (L) ear, nasopharyngeal(NP)/oropharyngeal(OP) samples, PT post-treatment, P penicillin; E erythromycin, Cc clindamycin, Te tetracycline, C chloramphenicol, Sxt co-trimoxazol, S sensitive to all tested antibiotics, PMEN Pneumococcal Molecular Epidemiology Network, aPredicted founders were assigned by comparing tested strain collection MLST data with whole MLST database