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Table 2 Normalized gene expression values of whole blood leukocytes samples of leprosy patients with reactions (n = 94) and leprosy patients without reactions (n = 57)

From: Whole blood profiling of leprosy type 1(reversal) reactions highlights prominence of innate immune response genes

Reaction vs No Reaction
Gene Description log fold change p.value*
CCL2 C-C Motif Chemokine Ligand 2 4.04 0.0016
PARK parkinson protein 2, E3 ubiquitin protein ligase 3.27 0.0036
ALOX5 Arachidonate 5-Lipoxygenase 2.99 0.0108
TLR7 Toll Like Receptor 7 2.98 0.011
LRRK2 Leucine Rich Repeat Kinase 2 3.09 0.0161
IFNB interferon beta 1 2.36 0.0228
TLR10 Toll Like Receptor 10 3.07 0.0236
IL18 Interleukin 18 2.34 0.0326
TLR3 Toll Like Receptor 3 2.74 0.0338
CLEC5A C-Type Lectin Domain Containing 5A 2.81 0.0446
RR vs No Reaction
 CCL2 C-C Motif Chemokine Ligand 2 4.31 0.0002
 TLR7 Toll Like Receptor 7 3.81 0.0012
 PARK parkinson protein 2, E3 ubiquitin protein ligase 3.16 0.002
 ALOX5 Arachidonate 5-Lipoxygenase 3.32 0.0044
 LRRK2 Leucine Rich Repeat Kinase 2 3.28 0.0056
 IFNB interferon beta 1 2.64 0.0104
 TLR10 Toll Like Receptor 10 3.08 0.0122
 TLR3 Toll Like Receptor 3 3.04 0.0122
 IL18 Interleukin 18 2.65 0.014
 OAS1 2′-5′-oligoadenylate synthetase 1 2.51 0.0376
 IL15 Interleukin 15 2.42 0.0446
ENL vs No Reaction
 PARK parkinson protein 2, E3 ubiquitin protein ligase 2.13 0.0436
ENL vs RR
 TLR7 Toll Like Receptor 7 −2.72 0.0214
  1. *The genes were defined as differentially expressed by the criterion of p-value adjusted for multiple comparisons. Bayesian statistical analysis used a log fold change cutoff of > 1 and adjusted p value of < 0.05. - Abbreviations: RR reversal reaction, ENL erythema nodosum leprosum