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Table 5 Performance of early-phase, late-phase, dual-phase and Day3–6 models

From: Methods to discriminate primary from secondary dengue during acute symptomatic infection

  Performance
AUC (95% CI) Accuracy Sens. Spec. PPV NPV
Early-phase models (102 primary vs 135 secondary dengue)
 Panbio Indirect IgG 0.89 (0.84–0.93) 0.87 0.91 0.82 0.87 0.88
 In-house anti-E indirect IgG 0.81 (0.75–0.86) 0.77 0.73 0.82 0.84 0.69
 In-house capture IgG 0.83 (0.77–0.89) 0.83 0.81 0.86 0.89 0.77
 In-house capture IgM/IgG ratio 0.82 (0.76–0.88) 0.82 0.86 0.76 0.83 0.80
Late-phase models (98 primary vs 116 secondary dengue)
 Panbio Indirect IgG 0.89 (0.85–0.93) 0.85 0.93 0.74 0.81 0.90
 In-house anti-E indirect IgG 0.73 (0.67–0.80) 0.71 0.82 0.59 0.70 0.73
 In-house capture IgG 0.85 (0.80–0.91) 0.85 0.92 0.77 0.82 0.89
 In-house capture IgM/IgG ratio 0.90 (0.86–0.94) 0.86 0.94 0.77 0.83 0.91
Dual-phase models (95 primary vs 109 secondary dengue)
 Panbio Indirect IgG 0.90 (0.86–0.94) 0.86 0.89 0.83 0.86 0.87
 In-house anti-E indirect IgG 0.79 (0.72–0.85) 0.74 0.72 0.77 0.78 0.70
 In-house capture IgG 0.86 (0.81–0.92) 0.85 0.91 0.79 0.83 0.88
 In-house capture IgM/IgG ratio 0.90 (0.86–0.94) 0.86 0.93 0.79 0.83 0.90
Days 3–6 models (90 primary vs 102 secondary dengue)
 Panbio Indirect IgG 0.92 (0.88–0.96) 0.88 0.92 0.82 0.85 0.90
 In-house anti-E indirect IgG 0.82 (0.76–0.89) 0.79 0.79 0.79 0.81 0.77
 In-house capture IgG 0.89 (0.84–0.94) 0.88 0.91 0.83 0.86 0.89
 In-house capture IgM/IgG ratio 0.93 (0.89–0.96) 0.88 0.95 0.79 0.84 0.93