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Table 2 Impact of precise co-morbidities on the development of sepsis

From: Progression into sepsis: an individualized process varying by the interaction of comorbidities with the underlying infection

Co-morbidity Odds ratio 95% confidence intervals p-value
Patients with acute pyelonephritis
 Type 2 diabetes mellitus 1.31 1.02–1.68 0.033
 Chronic heart failure 1.93 1.39–2.69 < 0.0001
 Chronic renal disease 29.31 9.26–92.86 < 0.0001
 Non-metastatic solid tumor malignancy 2.03 1.40–2.89 < 0.0001
 Corticosteroid intake 2.08 1.08–3.98 0.028
 Stroke 1.70 1.21–2.39 0.002
 Dementia 1.97 1.37–2.84 < 0.0001
Patients with community-acquired pneumonia
 Type 2 diabetes mellitus 1.73 1.06–2.82 0.027
 Chronic heart failure 1.99 1.13–3.49 0.016
 Coronary heart disease 3.72 1.69–8.19 0.001
 Dementia 3.44 1.64–7.24 0.001
Patients with intraabdominal infections
 Type 2 diabetes mellitus 3.29 2.15–5.03 < 0.0001
 Chronic renal disease 26.77 3.51–204.37 0.002
 Corticosteroid intake 3.86 1.41–10.53 0.008
 Atrial fibrillation 2.73 1.41–5.28 0.003
 Dementia 9.33 3.79–22.97 < 0.0001
 Liver cirrhosis 9.16 1.06–79.53 0.044
Patients with primary bacteremia
 Dementia 8.55 1.12–65.20 0.038
  1. Only variables remaining significant after the final step of logistic forward conditional regression analysis are included