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Table 1 Comparison of demographics of patients without sepsis and with sepsis in relation to the underlying infection

From: Progression into sepsis: an individualized process varying by the interaction of comorbidities with the underlying infection

  Acute pyelonephritis Community-acquired pneumonia Intra-abdominal infections Primary bacteremia
No sepsis Sepsis p No sepsis Sepsis p No sepsis Sepsis p No sepsis Sepsis p
Number of patients 542 901   146 853   399 334   81 253  
Male gender (n, %) 145 (26.8) 361 (40.0) < 0.0001 78 (53.4) 473 (55.4) 0.897 180 (45.2) 148 (45.1) 1.000 40 (49.4) 123 (48.6) 1.000
Age (mean ± SD, years) 61.1 ± 22.0 74.8 ± 15.3 < 0.0001 61.4 ± 20.2 75.3 ± 14.9 < 0.0001 55.4 ± 24.3 74.7 ± 14.8 < 0.0001 63.3 ± 19.7 72.9 ± 14.5 < 0.0001
APACHE II score (mean ± SD) 9.2 ± 6.0 16.5 ± 7.4 < 0.0001 8.4 ± 4.8 18.4 ± 7.6 < 0.0001 7.5 ± 4.9 17.5 ± 8.9 < 0.0001 9.2 ± 4.6 19.8 ± 7.5 < 0.0001
SOFA score (mean ± SD) 0.4 ± 0.5 5.9 ± 3.0 < 0.0001 0.7 ± 0.5 5.8 ± 3.2 < 0.0001 0.2 ± 0.5 5.3 ± 3.0 < 0.0001 0.5 ± 0.5 5.9 ± 3.4 < 0.0001
CCI (mean ± SD) 3.0 ± 2.5 5.0 ± 2.6 < 0.0001 2.7 ± 2.3 4.8 ± 2.4 < 0.0001 2.3 ± 2.3 4.6 ± 2.4 < 0.0001 3.0 ± 2.0 4.5 ± 2.4 < 0.0001
28-day mortality (n, %) 21 (3.9) 208 (23.1) < 0.0001 7 (4.8) 323 (37.9)* < 0.0001 17 (4.3) 109 (32.6)* < 0.0001 4 (4.9) 98 (38.6)* < 0.0001
  1. Abbreviations: APACHE acute physiology and chronic health evaluation, CCI Charlson’s comorbidity index, SOFA sequential organ failure assessment
  2. *p < 0.0001 compared to the respective mortality of acute pyelonephritis