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Table 2 Timing of clinical events in 199 patients hospitalised with severe dengue in 2014

From: Prediction of mortality in severe dengue cases

  All (N = 199) Died (N = 20) Survived (N = 179) p-value
  n n (%) or median (IQR) n n (%) or median (IQR) n n (%) or median (IQR)
1Day of admission 199 4.00 (2.81–5.00) 20 3.51 (2.58–4.38) 179 4.03 (2.93–5.00) 0.29
2Day of development of severe dengue 198 4.63 (3.56–5.67) 20 4.07 (3.22–5.81) 178 4.65 (3.66–5.67) 0.39
3Day of defervescence 194 4.96 (3.92–6.04) 18 4.08 (3.00–5.13) 176 5.02 (4.03–6.13) 0.05
4Day of outcome 199 8.75 (7.16–11.0) 20 6.81 (4.91–12.82) 179 8.80 (7.46–10.67) 0.08
Phase at admission, febrile 194 153 (78.8) 18 10 (55.6) 176 143 (81.3) 0.03a
Phase at severe dengue diagnosis, febrile 193 114 (59.1) 18 6 (33.3) 175 108 (61.7) 0.02
Severe dengue upon presentation 198 73 (36.9) 20 8 (40.0) 178 65 (36.5) 0.76
5Day of nadir WBC 199 4.63 (3.75–5.71) 20 3.74 (2.93–5.34) 179 4.71 (3.88–5.73) 0.07
6Day of nadir platelet 199 5.50 (4.64–6.50) 20 4.79 (3.40–6.96) 179 5.54 (4.79–6.50) 0.11
7Day of lowest serum bicarbonate 197 5.00 (3.92–6.04) 20 5.36 (3.56–8.94) 177 4.92 (3.96–5.92) 0.15
8Day of highest serum lactate 190 5.38 (4.13–6.60) 20 5.44 (3.93–9.70) 170 5.35 (4.13–6.50) 0.32
9Day of highest serum ALT 198 5.56 (4.42–6.75) 20 5.41 (4.05–7.02) 178 5.58 (4.42–6.75) 0.88
10Day of highest serum AST 194 5.35 (4.29–6.54) 20 5.26 (4.18–7.39) 174 5.35 (4.38–6.50) 0.81
11Day of highest serum creatinine 199 4.67 (3.67–5.79) 20 4.81 (4.00–8.38) 179 4.67 (3.58–5.71) 0.10
  1. n count of non-missing observations; aFisher’s exact test; IQR interquartile range, WBC white blood cell count, AST aspartate transaminase, ALT alanine transaminase; 1–11 These are days from onset of fever