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Table 2 Predictors of mortality in the identified studies, if any

From: High mortality in patients with Mycobacterium avium complex lung disease: a systematic review

Data set Negative association with all-cause mortality Positive association with all-cause mortality Reference
1 Surgical treatment   Yeager 1973 [12]
2   Male sex Age ≥ 70 years Presence of systemic and/or respiratory comorbidity FC disease BMI < 18.5 kg/m2 Anaemia Hypoalbuminemia Erythrocyte sedimentation rate ≥ 50 mm/h Hayashi 2012 [13]
3   High Charlson comorbidity index Presence of FC lesions Malignancy Ito 2012 [14]
4 NB disease FC disease FC + NB disease Usual interstitial pneumonia Emphysema Other lung disease Yamakawa 2013 [15]
5 Prior tuberculosis Bronchiectasis Asthma Male sex Older age Chronic obstructive pulmonary disease Interstitial lung disease Lung cancer HIV infection Cystic fibrosis Bone marrow transplant Morimoto 2014 [16]
6   Chronic pulmonary aspergillosis Cavitation Emphysema Zoumot 2014 [17]
7   Male sex Age ≥ 70 years BMI < 18.5 kg/m2 Absence of bloody sputum hypoalbuminaemia Erythrocyte sedimentation rate > 40 mm/h Gochi 2015 [18]
8,9   Male sex Age ≥ 70 years Malignancy, including lung cancer BMI < 18.5 kg/m2 Lymphocyte count < 1000/μl FC disease Kumagai 2017 [19]a
10   Male sex Age ≥ 65 years High comorbidity level Positive smear Andréjak 2010 [20]
11 NTM-PD with multiple species of NTM isolated Male sex Increasing age Comorbid conditions Marras 2017 [21]
12   Older age Low BMI Pneumonectomy Remnant cavitary lesions following pulmonary resection Asakura 2017 [22]a
13,14   Lung cancer Novosad 2017 [23]a
15   Increasing age Male sex Involvement of > 1 lung zone Low initial body weight Research Committee of the British Thoracic Society 2002 [24]
16,17 Adding clarithromycin vs. ciprofloxacin to rifampicin and ethambutol therapy regimen   Jenkins 2008 [25]
  1. BMI body mass index, FC fibrocavitary disease, HIV human immunodeficiency virus, NB nodular bronchiectatic disease, NTM nontuberculous mycobacteria, NTM-PD nontuberculous mycobacterial pulmonary disease
  2. aFactors found to be significant by multivariate analysis are listed