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Table 1 Performance characteristics of LPA for the detection RIF, INH, OFX, KAN and EMB

From: Comparison of line probe assay to BACTEC MGIT 960 system for susceptibility testing of first and second-line anti-tuberculosis drugs in a referral laboratory in South Africa

Drug No of isolates LPA + MGIT R LPA + MGIT S LPA R MGIT S LPA S MGIT R Sensitivity (%) Specificity (%) PPV (%) NPV (%) Agreement (%) K-Value
aRIF 97 14 73 10 0 100 (76.8–100) 87.9(78.9–94.1) 58.3 (43.9–71.5) 100 89.7 0.68
aINH 97 43 51 3 0 100 (91.8–100) 94.4 (84.6–98.8) 93.5 (82.7–97.7) 100 96.9 0.93
aOFL 90 9 74 7 0 100 (66.3–100) 91.4 (83.0–96.4) 56.2(38.8–72.3) 100 92.2 0.68
aKAN 90 3 85 2 0 100 (29.2–100) 97.7(91.9–99.7) 60.0(27.60–85.5) 100 97.8 0.74
aEMB 90 15 58 7 10 60 (38.7–78.9) 89.2(79.06–95.56) 68.2(49.8–82.2) 85.3(78.1–90.4) 81.1 0.54
  1. a RIF Rifampicin, INH Isoniazid, OFX Ofloxacin, KAN Kanamycin, EMB Ethambutol, S susceptible, R resistant, LPA Line Probe Assay, PPV positive predictive value, NPV negative predictive value