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Table 3 Characteristics of publications – Clinical trials (N = 11)

From: Mathematical models used to inform study design or surveillance systems in infectious diseases: a systematic review

First author, year Infection   Population Model   Main outcome Design outcome(s) Remarks
  Epidemiological category Name   Type a Structured/Network b    
Atlas, 1993 [28] Human, water-borne Cryptosporidium Volunteer subjects Compartmental - deterministicc No/No Probability of infection - Sample size Exprimental study
Lipsitch, 2001 [29] Human, respiratory Streptococcus pneumoniae Not described Compartmental - deterministic No/No Simple and conditional odds-ratios - Timing of sampling
Wu, 2002 [30]; Wu, 2005 [39] Human, STI HIV Within-host (cells) Compartmental - deterministic No/No HIV viral load change - Timing of sampling - Frequency - Number - Sample size - Power Statistical model used for fitting data
Clermont, 2004 [31] Human, bacterial Generic Gram-negative pathogen Within-host (virtual infected patients) Compartmental - deterministic Yes/No Identify people who will well respond to the anti-tumor necrosis factor - Whom
Hallett, 2008 [32] Human, STI HIV Heterosexual population Compartmental - deterministic Yes/Yes HIV incidence rate ratio - Follow-up - Sample size - Power
Dimitrov, 2013 [33] Human, STI HIV Heterosexual population representative of sub-saharan Africa Compartmental - deterministic Yes/No HIV incidence - Sample size - Power
Nishiura, 2013 [34] Animal influenza A viruses Ferret in cages Compartmental - stochastic No/No Number of pairs to include in 1-to-1 transmission studies - Sample size - Power
Cori, 2014 [35]; Hayes, 2014 [40] Human, STI HIV Adults, 18-44y, South Africa and Zambia Compartmental - deterministic Yes/Yes HIV incidence - Monitoring - Power Effectively used to plan a three-arm cluster RCT
Cuadros, 2014 [36] Human, STI HIV Serodiscordant couples; male population IBM No/Yes HIV incidence - Power
Scott, 2014 [37] Human, respiratory Streptococcus pneumoniae Infants Compartmental - deterministic Yes/No Vaccine efficacy against acquisition and/or duration - Follow-up - Timing of sampling - Monitoring
Herzog, 2015 [38] Human, STI Chlamydia trachomatis Women Compartmental - deterministic No/No Pelvic inflammatory disease incidence - Follow-up - Sample size - Power
  1. amodel type: IBM – individual based model; b structured: population structure is reflected in model, network: network of contacts between individuals is explicitly modelled; c model seen as compartmental model