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Table 3 Univariable analysis of potential predictors of death amongst transplant recipients (n = 438)

From: Cytomegalovirus viraemia and mortality in renal transplant recipients in the era of antiviral prophylaxis. Lessons from the western Australian experience

Variable Number Number of deaths (%) Death rate per 100,000 patient days (95% CI) p-value
All cases 438 55 (12.6) 7.9 (6.0, 10.2)  
Transplant Hospital
 SCGH 232 29 (12.5) 7.9 (5.5, 11.3) 1.0
 RPH 206 26 (12.6) 7.8 (5.3, 11.5)  
CMV viral load of ≥600 copies/ml
 No 364 35 (9.6) 5.8 (4.2, 8.0) <0.001
 Yes 74 20 (27.0) 21.0 (13.6, 32.6)  
CMV viral load (copies/ml)
  < 600 364 35 (9.6) 5.8 (4.2, 8.0)  
 600–4999 42 10 (23.8) 18.7 (9.7, 35.9) <0.001
  ≥ 5000 32 10 (31.3) 23.5 (13.0, 42.4) 0.001
Sex
 Female 166 25 (15.1) 9.2 (6.2, 13.7) 0.30
 Male 272 30 (11.0) 7.0 (4.9, 10.0)  
Deceased donor
 No 192 17 (8.9) 5.2 (3.2, 8.3) 0.02
 Yes 246 38 (15.5) 10.2 (7.4, 14.0)  
Donor aged ≥60
 No 317 35 (11.0) 6.8 (4.9, 9.5) 0.10
 Yes 121 20 (16.5) 10.8 (7.0, 16.8)  
Graft failure
 No 390 47 (12.1) 7.6 (5.7, 10.1) 0.51
 Yes 48 8 (16.7) 9.7 (4.9, 19.4)  
Age ≥ 65 at transplant
 No 399 42 (10.5) 6.5 (4.8, 8.8) <0.001
 Yes 39 13 (33.3) 24.2 (14.1, 41.7)  
Lung Disease
 No 378 41 (10.9) 6.8 (5.0, 9.2) 0.02
 Yes 60 14 (23.3) 14.6 (8.6, 24.6)  
Cerebrovascular disease
 No 407 41 (10.1) 6.2 (4.6, 8.4) <0.001
 Yes 31 14 (45.1) 34.5 (20.4, 58.3) <0.001
Vascular disease other than cerebrovascular
 No 104 36 (10.8) 6.7 (4.8, 9.3) 0.05
 Yes 334 19 (18.3) 11.7 (7.5, 18.4)  
Diabetes
 No 293 35 (12.0) 7.5 (5.4, 10.4) 0.61
 Yes 145 20 (13.8) 8.6 (5.6, 13.3)  
HLA mismatch ≥2
 No 373 6 (10.2) 5.9 (2.6, 13.1) 0.45
 Yes 59 49 (13.1) 8.3 (6.2, 10.9)  
Maximum Panel Reactive Antibody level ≥ 50%
 No 366 46 (12.6) 7.8 (5.8, 10.4) 0.62
 Yes 61 9 (14.8) 9.2 (4.8, 17.7)  
Any cancer diagnosis
 No 352 42 (11.9) 7.5 (5.5, 10.2) 0.51
 Yes 86 13 (15.1) 9.2 (5.3, 15.8)  
Aboriginal
 No 387 40 (10.3) 6.4 (4.7, 8.8) 0.001
 Yes 51 15 (29.4) 19.3 (11.6, 32.0)  
Any rejection
 No 302 37 (12.3) 7.9 (5.7, 10.9) 0.99
 Yes 136 18 (13.2) 7.8 (4.9, 12.4)  
Severe rejection
 No 404 49 (12.1) 7.7 (5.8, 10.1) 0.54
 Yes 34 6 (17.7) 9.9 (4.4, 21.9)  
Healthy weight (BMI 19–25) at transplant
 No 272 35 (12.9) 8.3 (5.9, 11.5) 0.78
 Yes 159 20 (12.6) 7.6 (4.9, 11.8)  
Current smoker
 No 398 48 (12.1) 7.6 (5.7, 10.1) 0.45
 Yes 40 7 (17.5) 10.2 (4.9, 21.5)