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Table 1 Study 1. The performance characteristics of SOFIA®RSV, RSV DFA, and cell culture (MRC5)

From: SOFIA®RSV: prospective laboratory evaluation and implementation of a rapid diagnostic test in a pediatric emergency ward

  Sensitivity (%) (95% CI) Specificity (%) (95% CI) Positive predictive value (%) (95% CI) Negative predictive value (%)
  SOFIA RSV DFA RSV MRC5 RSV SOFIA RSV DFA RSV MRC5 RSV SOFIA RSV DFA RSV MRC5 RSV SOFIA RSV DFA RSV MRC5 RSV
Total (n = 401) 78.8 (70.6–85.7) 63.4 (54.2–71.9) 42.2 (33.4–51.5) 98.5 (96.4–99.6) 99.6 (98.0–100.0) 99.6 (98.0–100.0) 96.0 (90.2–98.9) 98.7 (93.1–100.0) 98.0 (89.9–100.0) 91.3 (87.6–94.3) 86.0 (81.7–89.6) 79.6 (75.0–83.7)
Infant group (n = 199) 95.0 (86.8–98.1) 81.0 (71.2–88.8) 54.0 (43.0–65.0) 99.0 (95.2–100.0) 100.0 (97.4–100.0) 100.0 (95.2–100.0) 99.0 (93.3–100.0) 100.0 (95.7–100.0) 98.0 (88.7–100.0) 96.6 (90.4–98.6) 87.6 (80.8–92.8) 74.3 (66.6–81.1)
Children group (n = 100) 45.0 (23.1–68.5) 25.0 (8.7–49.1) 30.0 (11.9–54.3) 97.5 (91.3–99.7) 98.7 (93.2–100.0) 98.7 (96.3–100.0) 82.0 (48.2–97.7) 83.3 (35.9–99.6) 100.0 (60.7–100.0) 88.0 (79.0–93.7) 84.0 (75.0–90.8) 85.0 (76.3–91.6)
Adult group (n = 102) 59.0 (32.9–81.6) 23.5 (6.8–49.9) 0.0 (0.0–16.2) 100.0 (96.5–100.0) 100.0 (96.5–100.0) 100.0 (96.5–100.0) 100.0 (74.1–100.0) 100.0 (47.3–100.0) / 92.0 (84.9–96.9) 86.7 (78.4–92.7) 83.0 (74.7–90.0)
  1. Sensitivities, specificities, positive and negative predicted values (PPV and NPV) of SOFIA®RSV, RSV DFA, and cell culture (MRC5) calculated on the 401 respiratory samples of study 1. The PCR test was used as the reference test