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Table 2 Univariate linear regression with TMAO as the dependent variable

From: Microbiota-dependent metabolite and cardiovascular disease marker trimethylamine-N-oxide (TMAO) is associated with monocyte activation but not platelet function in untreated HIV infection

  Untreated (n = 49) ART Treated (n = 49)
Standardized β coefficients P Standardized β coefficients P
Clinical characteristics:
 Age (years) 0.180 0.21 0.290 0.04
 Gender, male 0.137 0.34 0.110 0.94
 Current smoker, 0.129 0.39 −0.182 0.24
 Current CD4+ T cell count (cells/μl) 0.035 0.81 0.084 0.57
 Nadir CD4+ T cell count (cells/μl) −0.081 0.58 0.087 0.55
 HIV-RNA (103 copies/ml) −0.010 0.94 NA NA
 HIV duration 0.078 0.59 0.070 0.64
Class of ART
 NRTI containing (n = 44) NA NA 0.043 0.78
 NNRTI containing (n = 22) NA NA 0.135 0.38
 PI containing (n = 23) NA NA 0.145 0.34
 II containing (n = 4) NA NA −0.024 0.87
 Abacavir containing (n = 16) NA NA −0.126 0.41
Standard coagulation
 D-dimer 0.051 0.74 0.209 0.16
 Fibrinogen 0.091 0.55 0.183 0.24
 APTT 0.117 0.43 0.171 0.27
 Coagulation factors 2–7-10 0.043 0.77 0.032 0.83
Platelet aggregation (Multiplate):
 ADP test (Units) −0.074 0.62 −0.177 0.23
 ASPI test (Units) −0.156 0.29 −0.243 0.10
 COL test (Units) −0.080 0.59 −0.211 0.15
 TRAP test (Units) −0.119 0.42 −0.220 0.13
 Hypocoagulable in ≥2/4 tests 0.007 0.97 0.147 0.32
 Hypercoagulable in ≥2/4 tests −0.172 0.24 NA NA
Markers of Microbial translocation and inflammation:
 sCD14 (ρg/ml) 0.454 0.001 −0.157 0.28
 LPS (ρg/ml) −0.019 0.90 0.047 0.75
 hsCRP −0.016 0.92 0.028 0.37
  1. Univariate linear regression with trimethylamine-N-oxide (TMAO) as the dependent variable. Standardized regression coefficients and P values are given. Standard coagulation, and platelet impedance aggregometry are given as continuous variables and classified as hypo- and hypercoagulable according to normal range
  2. APTT activated partial thromboplastin time, ART anti-retroviral therapy, ASPI arachidonic acid, COL collagen, FEU fibrinogen equivalent units, II integrase Inhibitor, n number, NA not applicable, NRTI nucleotide/nucleoside reverse transcription inhibitor, NNRTI non-nucleoside reverse transcription inhibitor, PI protease Inhibitor, sCD14 soluble CD14, TRAP thrombin-receptor activating peptide
  3. Significant associations are marked in bold