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Table 1 Patient characteristics

From: Development and validation of a prognostic scoring model for Mycobacterium avium complex lung disease: an observational cohort study

  Cohort 1, N = 368 Cohort 2, N = 118 P-value
Male 151 (41.0) 45 (38.1) 0.592
Age, years 72 ± 10 70 ± 10 0.019
Smoking history    0.264
 Current 20 (5.4) 4 (3.4)  
 Past 224 (60.9) 76 (64.4)  
 Never 114 (31.0) 38 (32.2)  
 Unknown 10 (2.7) 0 (0.0)  
Comorbidity
 Respiratory diseases 110 (29.9) 41 (34.7) 0.361
  Old pulmonary tuberculosis 31 (8.4) 24 (20.3) 0.001
  Emphysema 40 (10.9) 14 (11.9) 0.739
  Interstitial pneumonia 29 (7.9) 6 (5.1) 0.413
  Lung cancer 31 (8.4) 6 (5.1) 0.318
  Asthma 12 (3.3) 6 (5.1) 0.402
  Bronchiectasis 20 (5.4) 5 (4.2) 0.811
 Systemic diseases
  Chronic heart diseases 45 (12.2) 18 (15.3) 0.431
  Diabetes mellitus 40 (10.9) 10 (8.5) 0.492
  Collagen vascular diseases 27 (7.3) 13 (11.0) 0.247
  Malignancya 86 (23.4) 27 (22.9) 0.999
  Chronic liver diseases 8 (2.2) 6 (5.1) 0.115
  Neurological diseases 33 (9.0) 12 (10.2) 0.716
  Chronic renal diseases 7 (1.9) 9 (7.6) 0.005
Steroid use 14 (3.8) 7 (6.0) 0.306
Immunosuppressant useb 19 (5.2) 5 (4.3) 0.811
BMI, kg/m2 19.6 ± 3.4 20.3 ± 3.2 0.090
BT, °C 36.7 ± 0.6 36.7 ± 0.9 0.735
Laboratory findings
 Lymphocytes,/μL 1400 ± 680 1300 ± 480 0.014
 Hb, g/dL 12.4 ± 1.8 13 ± 1.6 0.001
 Alb, g/dL 3.9 ± 0.6 4.2 ± 0.4 <0.001
 CRP, mg/dL 1.7 ± 3.5 3.7 ± 7.4 <0.001
 Cre, mg/dL 0.79 ± 0.73 0.9 ± 0.99 0.206
Diagnosis methods    <0.001
 Sputum 263 (71.5) 115 (97.5)  
 Bronchoscopy 105 (28.5) 3 (2.5)  
Bacteriological examinations
 Smear positive 64 (17.4) 38 (32.2) 0.001
 Culture ≥2+ 74 (20.1) NE  
 Macrolide resistant 0 (0.0) 0 (0.0) NE
Radiological findings    0.337
 NB 298 (81.0) 101 (85.6)  
 FC 41 (11.1) 14 (11.9)  
 FC/NB 6 (1.6) 0 (0.0)  
 Otherc 35 (9.5) 3 (2.5)  
Deaths 75 (20.5) 20 (16.9) 0.505
Causes of death    0.864
 MAC-specific death 29 (38.7) 9 (45.0)  
 Malignancy 20 (26.7) 4 (20.0)  
 Other 20 (26.7) 5 (25.0)  
 Unknown 6 (0.1) 1 (5.0)  
  1. Data are n (%) or mean ± standard deviation
  2. BMI body mass index, BT body temperature, Hb hemoglobin, Alb serum albumin, CRP C-reactive protein, Cre creatinine, NE not evaluated, NB nodular/bronchiectatic disease, FC fibrocavitary disease
  3. aMalignancy includes lung cancer
  4. bImmunosuppressants included methotrexate, cyclosporin, azathioprine, cyclophosphamide, tacrolimus, etanercept, salazopyrin, mizoribine, and bucillamine
  5. cOther included unclassifiable and disseminated diseases