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Column 1

2

3

4

5

6

7

8


Symptom

Seroconversion visit
n%

HIV negative visit
n%

OR
(95% CI)

Symptom based model aOR
(95% CI)^{b}

Beta coefficient^{c,d}

Combined model aOR (95% CI)^{e}

Beta coefficient^{c,f}


Total^{g}

175

17,271
     
Symptom

Diarrhea

30

17.1

1011

5.9

3.3 (2.2–4.8)

1.3 (0.8–2.1)

0.3

1.5 (0.9–2.4)

0.4

Fatigue

42

24.0

1867

10.8

2.6 (1.8–3.6)

1.2 (0.8–1.9)

0.2

1.4 (0.9–2.2)

0.3

Fever

76

43.4

1623

9.4

7.2 (5.4–9.8)

5.0 (3.5–7.1)^{h}

1.6

4.7 (3.2–7.0)^{h}

1.6

Genital ulcers

11

6.3

324

1.9

3.5 (1.9–6.4)

2.6 (1.3–5.0)^{h}

0.9

1.6 (0.6–4.0)

0.5

Headache

18

10.3

980

5.7

1.9 (1.2–3.1)

0.7 (0.4–1.3)

−0.3

0.8 (0.4–1.5)

−0.2

Lymphadenopathy

27

15.4

418

2.4

7.2 (4.7–10.9)

3.3 (2.1–5.4)^{h}

1.2

4.4 (2.6–7.3)^{h}

1.5

Myalgia

25

14.3

869

5.0

3.1 (2.0–4.7)

1.1 (0.7–1.9)

0.1

1.4 (0.8–2.4)

0.3

Nausea

18

10.3

526

3.1

3.6 (2.2–5.8)

0.8 (0.4–1.7)

−0.2

0.9 (0.4–1.9)

−0.1

Night sweats

32

18.3

832

4.8

4.3 (3.0–6.4)

1.2 (0.8–2.0)

0.2

1.2 (0.7–2.1)

0.2

Oral thrush

4

2.3

36

0.2

10.8 (3.8–30.7)

5.0 (1.5–16.3)^{h}

1.6

5.6 (1.4–22.3)^{h}

1.7

Rash

11

6.3

564

3.3

2.0 (1.1–3.6)

1.2 (0.6–2.4)

0.2

0.6 (0.3–1.4)

−0.5

Sore throat

31

17.7

1316

7.6

2.6 (1.7–3.8)

1.0 (0.7–1.6)

0.0

0.9 (0.5–1.4)

−0.2

Vomiting

17

9.7

336

2.0

5.3 (3.2–8.8)

1.8 (0.9–3.8)

0.6

1.4 (0.6–3.3)

0.4

Weight loss

11

6.3

205

1.2

5.5 (2.9–10.2)

1.9 (1.0–3.9)

0.7

2.4 (1.1–5.2)^{h}

0.9

Risk factor

Gonorrhea^{i,j}

12

6.9

181

1.1

6.5 (3.6–12.0)
  
4.9 (2.3–10.2)^{h}

1.6

Receptive CLAI^{i}

97

55.4

5651

32.7

2.7 (2.0–3.7)
  
3.0 (2.1–4.2)^{h}

1.1

>5 sexual partners^{i,k}

100

57.1

7659

44.4

2.4 (1.7–3.4)
  
2.5 (1.7–3.6)^{h}

0.9


aOR adjusted odds ratio. CI confidence interval, CLAI condomless anal intercourse, OR odds ratio

^{a}In Amsterdam Cohort Studies, based on imputed data using the last observation carried forward method

^{b}14 symptoms in column 1 were included in a multivariable logistic regression model using generalized estimating equations

^{c}Natural log of the adjusted odds ratio, rounded to one decimal

^{d}Based on the adjusted odds ratios of the symptombased model (column 5)

^{e}14 symptoms and 3 risk factors in column 1 were included in a multivariable logistic regression model using generalized estimating equations

^{f}Based on the adjusted odds ratios of the combined symptom and risk factor model (column 7)

^{g}Due to missing values, the denominator of columns 2 and 3 are sometimes not equal to 175 respectively 17,271. Data missing for the following variables: fever, 1 missing; genital ulcers, 3 missings; gonorrhea, 2072 missings; receptive condomless anal intercourse, 162 missings; >5 sexual partners, 56 missings

^{h}Significantly associated with HIV1 seroconversion

^{i}In the preceding 6 months

^{j}Selfreported

^{k}Only male sex partners, compared to ≤5 sexual partners