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Table 1 Description of model parameters and their associated values (ranges)

From: Assessing the effect of patient screening and isolation on curtailing Clostridium difficile infection in hospital settings

Parameter Description Value (range) Source
R 0 basic reproduction number 1.07 (0.55–1.99) 2.6 (1–7) [14] [34]
r hospital admission rate 0.17 day−1 assumed to be the same as discharge rate
δ fraction of admitted patients with CDI symptoms 1.2 × 10−4 Calculated based on the rate of 6.9 per 10,000 patient-days estimated over 82 periods of 4 weeks [20]
θ fraction of admitted patients without CDI symptoms who are screened 0.925 (0–1) [20]
b s fraction of screened admitted patients who are susceptible 0.952 (0–1) [20]
η fraction of screened patients who are colonized and develop immune responses 0.6 (0.45–0.75) [14, 15]
α fraction of screened admitted patients who are susceptible and receive antibiotic treatment 0.22 (0.15–0.29) [14]
σ fraction of in-hospital patients who are screened following exposure to CDI 0.9 (0–1) assumed, varied in sensitivity analysis
f fraction of colonized patients who develop immune responses 0.6 (0.45–0.75) [14, 15]
ε rate of developing CDI symptoms in colonized patients 0.2 (0.14–0.26) day−1 [14, 15]
τ + recovery rate of damaged gut flora 0.011 day−1 [37]
τ rate of antibiotic treatment damaging gut flora 0.11 day−1 [36]
q fraction of CDI patients who are successfully treated 0.8 (0.56–1) [14, 15]
μ discharge rate of hospital patients without symptomatic infection 0.17 day−1 [14, 15]
μ I CDI-caused death rate 0.0012 (0.001–0.01) day−1 [14, 15]
ρ rate of symptoms resolution for CDI patients under treatment 0.25 (0.143–0.33) day−1 [35]
γ recovery rate of CDI patients under treatment after symptoms resolution 0.2 (0.143–0.33) day−1 [14, 15]
κ relative transmissibility of colonized patients without symptoms 0.5 (0.3–0.7) assumed, varied in sensitivity analysis
ν reduction of transmissibility due to immune responses 0.5 (0.3–0.7) assumed, varied in sensitivity analysis
ξ effectiveness of isolation for CDI patients 0.8, 0.9, 1 (0.8–1) assumed, varied in sensitivity analysis
Ψ reduced risk of CDI in patients without antibiotic exposure 0.2 (0.06–0.55) [24]
π time-interval between sample collection and release of laboratory results 1 (1–3) days [28, 31, 32]