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Table 1 Definition criteria of viral controller and non-viral controller groups investigated, according to the time of infection without ART, immunological and virological measurements

From: Immunological and virological characterization of HIV-1 viremia controllers in the North Region of Brazil

Groups according to disease progression Time of known infection Time of data collection Use of antiretroviral therapy Measurements of T CD4+ lymphocytes Measurements of HIV-1 viral load Important remarks
VC1: Viremia Controller 1 (Elite Controller) >6 years Since 2007 (minimum of 3 years of data) No ART >500 cells/mm3 <50 copies/mL (not detectable) No episodes of increase in viral load; counts of LTCD4+ greater than 500 cells/mm3; maintains stability for more than 6 years; no ART intervention
VC2: Viremia Controller 2 >6 years Since 2007 (minimum of 3 years of data) No ART >500 cells/mm3 ≤ Log10 4 (up to 10,000 copies/mL) Episodes of increase in viral load and decrease in counts of LTCD4+, independent of the number of occurrences, but with natural remission, representing no more than 50% of measurements; maintain control for more than 6 years without ART intervention
NC: Non-Viremia Controller >6 years Since 2007 (minimum of 3 years of data) No ART <500 cells/mm3 > Log10 4 (greater than 10,000 copies/mL)