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Table 4 Pattern of gene mutations detected by the MTBDRplus assay in 60 drug-resistant Mycobacterium tuberculosis isolates

From: Diagnostic accuracy and usefulness of the Genotype MTBDRplus assay in diagnosing multidrug-resistant tuberculosis in Cameroon: a cross-sectional study

Gene Band Gene region or mutations aINH monoresistant N = 6 aINH poly-resistant N = 5 aMDR-TB (N = 49)
rpoB
  WT1 506–509 6 5 49
  WT2 510–513 6 5 48
  WT3 513–517 6 5 46
  WT4 516–519 6 5 47
  WT5 518–522 6 5 49
  WT6 521–525 6 5 49
  WT7 526–529 6 5 46
  WT8 530–533 6 5 7
  MUT1 D516V 0 0 0
  MUT2A H526Y 0 0 0
  MUT2B H526D 0 0 3
  MUT3 S531L 0 0 41
KatG
  WT 315 5 1 19
  MUT1 S315T1 1 4 30
  MUT2 S315T2 0   0
inhA
  WT1 -15/−16 3 5 32
  WT2 -8 6 5 49
  MUT1 C15T 3 0 17
  MUT2 A16G 0 0 0
  MUT3A T8C 0 0 1
  MUT3B T8A 0 0 0
  1. aBy conventional drug susceptibility testing using the Bactec MGIT 960 system