You are viewing the site in preview mode

Skip to main content

Advertisement

Table 3 Univariate and multivariate analyses of prognostic factors for cervical cancer patients

From: Independent prognostic role of human papillomavirus genotype in cervical cancer

Variable Overall survival Disease free survival
3-Year Rate 5-Year Rate P e Adjusted HR P b 3-Year Rate 5-Year Rate P e Adjusted HR P f
(95% CI) (95% CI) (95% CI) f (95% CI) (95% CI) (95% CI)f
Age, years
  < 40 93.18 (80.33, 97.75) 93.18 (80.33, 97.75) 0.634 1.00   86.43 (72.24, 93.67) 78.58 (62.60, 88.34) 0.956 1.00  
  40–50 91.20 (84.67, 95.03) 85.39 (76.26, 91.21)   1.74 (0.49, 6.20) 0.390 83.84 (76.07, 89.26) 78.48 (68.81, 85.46)   0.72 (0.32, 1.60) 0.417
  > 50 91.75 (85.20, 95.47) 86.99 (79.22, 92.00)   1.09 (0.30, 4.04) 0.893 87.78 (80.55, 92.45) 78.01 (68.46, 84.99)   0.56 (0.25, 1.30) 0.177
Histologic typea
  SCC 91.77 (87.87, 94.46) 87.07 (81.97, 90.81) 0.943    85.79 (81.13, 89.37) 77.96 (71.96, 82.82) 0.478   
  AC/ASC 87.50 (38.70, 98.14) 87.50 (38.70, 98.14)     87.50 (38.70, 98.14) 87.50 (38.70, 98.14)    
FIGO stageb
  I 95.82 (89.23, 98.41) 94.73 (87.79, 97.77) <0.001 1.00   93.83 (86.78, 97.18) 86.60 (75.90, 92.76) <0.001 1.00  
  II 95.68 (90.63, 98.04) 88.83 (79.72, 94.00)   0.98 (0.27, 3.50) 0.970 89.86 (83.48, 93.87) 84.14 (76.10, 89.65)   1.20 (0.43, 3.36) 0.735
  III 74.66 (59.67, 84.76) 70.20 (54.87, 81.17)   3.40 (0.92, 12.52) 0.066 66.66 (51.44, 78.08) 53.52 (37.74, 66.96)   4.54 (1.53, 13.42) 0.006
  IV 60.00 (12.57, 88.18) 40.00 (5.20, 75.28)   9.91 (1.87, 52.39) 0.007 16.67 (0.77, 51.68) 16.67 (0.77, 51.68)   13.21 (3.24, 53.82) <0.001
Differentiation
  Poor 90.36 (81.64, 95.07) 86.83 (76.49,92.82) 0.383    83.23 (73.31, 89.71) 68.83 (55.26, 79.03) 0.068   
  Moderate 90.68 (83.80, 94.73) 88.08 (80.70,92.77)     88.27 (80.98, 92.88) 82.83 (73.70, 89.02)    
  Well 90.91 (50.81, 98.67) 72.73 (37.08,90.28)     63.64 (29.69, 84.52) 63.64 (29.69, 84.52)    
  Unclassified           
Treatment§
  Surgery 100 98.53 (90.02, 99.79) 0.004 1.00   96.05 (88.24, 98.71) 84.25 (66.36, 93.09) 0.019 1.00  
  Surgery plus CT/RT/CRT 100 93.75 (63.23, 99.10)   3.98 (0.25, 64.19) 0.331 95.00 (69.47, 99.28) 95.00 (69.47, 99.28)   0.43 (0.52, 3.56) 0.433
  CCRT 90.02 (83.99, 93.87) 82.55 (74.02, 88.49)   8.26 (0.87, 78.75 0.066 83.34 (76.34, 88.43) 73.83 (65.27, 80.60)   1.44 (0.44, 4.74) 0.545
  CR or RT 79.55 (64.38, 88.79) 79.55 (64.38, 88.79)   13.91 (1.59, 121.54) 0.017 73.37 (57.89, 83.91) 73.37 (57.89, 83.91)   1.92 (0.63, 5.88) 0.253
HPV16
  Negative 83.09 (73.10, 89.63) 81.77 (71.57, 88.60) 0.037 1.00   82.89 (72.81, 89.50) 75.71 (64.69, 83.71) 0.342   
  Positive 95.17 (91.21, 97.37) 88.93 (82.31, 93.17)   0.36 (0.18, 0.74) 0.005 87.07 (81.70, 90.95) 79.03 (71.40, 84.84)    
HPV18
  Negative 91.87 (87.80, 94.62) 87.58 (82.23, 91.40) 0.404    86.49 (81.69, 90.11) 78.76 (72.58, 83.71) 0.69   
  Positive 90.04 (72.14, 96.69) 83.12 (64.02, 92.62)     80.85 (62.18, 90.93) 74.63 (52.38, 87.60)    
HR-HPV speciesd
  Alpha-7 74.38 (58.47, 84.93) 71.81 (55.65, 82.94) <0.001 1.00   76.32 (60.41, 86.51) 62.96 (45.04, 76.47) 0.005 1.00  
  Alpha-9 94.34 (90.44, 96.67) 90.42 (84.82, 94.02)   0.17 (0.08, 0.37) <0.001 87.89 (82.93, 91.47) 80.88 (74.33, 85.92)   0.32 (0.17, 0.59) <0.001
HR-HPV pattern
  Single 90.90 (86.61, 93.86) 87.04 (81.66, 90.94) 0.939    85.47 (80.51, 89.25) 77.41 (71.06, 82.53) 0.389   
  Multiple 97.30 (82.32, 99.61) 87.77 (70.52, 95.24)     88.83 (72.85, 95.67) 85.54 (68.53, 93.75)    
  1. aSCC, squamous cell carcinoma; AC, adenocarcinoma; ASC, adeno-squamous carcinoma
  2. bFIGO, International Federation of Gynecology and Obstetrics
  3. cCT, chemotherapy; RT, radiotherapy; CRT, chemoradiotherapy; CCRT, concurrent chemoradiotherapy
  4. dHR-HPV, high risk human papillomavirus
  5. eCalculated by using the log-rank test. Bold values indicate P < 0.05
  6. fAdjusted for age, FIGO stage, and treatment in the Cox regression models