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Table 3 Association between KTR before initiation of cART, immune activation and reduction in immune activation at baseline and at 6, and 12 months of follow-up

From: Tryptophan catabolism and immune activation in primary and chronic HIV infection

  Primary HIV infection N = 14 Early presenters N = 16 Late presenters N = 19
ρ pvalue ρ pvalue ρ pvalue
CD8 + CD38 + HLA-DR+
 Baseline .867 .002 .534 .033 .311 .260
 After 6 months of cART −.417 .265 .670 .006 .152 .676
 After 12 months of cART −.800 .104 .451 .164 .145 .670
CD4 + CD38 + HLA-DR+
 Baseline .267 .488 .689 .003 .530 .051
 After 6 months of cART −.410 .273 .711 .003 .527 .117
 After 12 months of cART −.872 .054 .679 .022 .045 .894
ΔCD8 + CD38 + HLA-DR+
 After 6 months of cART .833 .010 .086 .771 .017 .966
 After 12 months of cART .900 .037 .345 .328 −.041 .905
ΔCD4 + CD38 + HLA-DR+
 After 6 months of cART .167 .693 .530 .051 .250 .516
 After 12 months of cART .900 .033 .600 .067 .273 .446
  1. P*: associations analyzed with Spearman’s test. Bold font if significant p value