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Table 2 Comparative analysis of the sub-samples’ characteristics

From: Antimicrobial consumption, costs and resistance patterns: a two year prospective study in a Romanian intensive care unit

Item SI SII SIII SIV SI-II p SI-III p SI-IV p SII-III p SII-IV p SIII-IV p
Average age [years(95% IC)](a) 58.23 (56.88-59.58) 62.90 (60.96–64.82) 61.32 (60.04–62.60) 60.10 (54.76–65.45) <0.001 0.004 0.345 0.165 0.325 0.623
Male [n(%)](b) 432 (61.98) 191 (55.52) 368 (60.43) 21 (45.65) 0.045 0.565 0.027 0.139 0.206 0.049
Female [n (%)](b) 265 (38.02) 153 (44.47) 241 (39.57) 25 (54.35)
Average no. days of ICU stay [days(95% IC)] (c) 4.11 (3.83–4.40) 6.70 (6.05–7.34) 16.06 (14.68–17.43) 14.08 (10.69–17.47) <0.001 <0.001 <0.001 <0.001 <0.001 0.926
Average no. days of antimicrobial drugs therapy [days(95% IC)] (c) 2.78 (2.62–2.93) 5.47 (4.96–5.96) 11.18 (10.28–12.06) 12.13 (9.31–14.95) <0.001 <0.001 <0.001 <0.001 <0.001 0.232
Average no. days of empirical therapy [days(95% IC)] (c) 2.78 (2.62–2.93) 3,96 (3.65–4.27) 4.75 (4.48–5.01) 4,85 (3.89–5.81) <0.001 <0.001 <0.001 0.035 0.132 0.915
Average no. days of definitive therapy [days(95% IC)] / 6,25 (5.24–7.27) 11.46 (10.24–12.68) 11,53 (8.61–14.46) / / / 0.005 0,001 0.449
Number of a antimicrobial drugs administered in the ICU [no.(95% IC)](b) 1.23 (1.19-1.27) 1.69 (1.58–1.60) 2.57 (2.42–2.72) 2.91 (2.36–3.47) <0.001 <0.001 <0.001 <0.001 <0.001 0.114
Number of antimicrobial drugs administered in the ICU as empirical therapy [no.(95% IC)] (b) 1.23 (1.19–1.27) 1,24 (1.18–1.29) 1.40 (1.35–1.46) 1,36 (1.21–1.52) 0.754 <0.001 0.026 <0.001 0.055 0.846
Number of antimicrobial drugs administered in the ICU as definitive therapy [no.(95% IC)] (b) / 1,84 (1.63–2.05) 2.45 (2.27–2.64) 2,93 (2.35–3.52) / / / 0.004 <0.001 0.111
Deaths [n (%)] (b) 196 (28.12) 179 (52.03) 361 (59.27) 30 (65.21) <0.001 <0.001 <0.001 0.030 0.092 0.428
Improved evolution [n (%)] (b) 475 (68.15) 155 (45.06) 211 (34.64) 16 (34.78) <0.001 <0.001 <0.001 0.001 0.187 0.985
Stationary & aggravated evolution [n (%)] (b) 26 (3.73) 9 (2.62) 37 (6.08) 0 (0) 0.348 0.048 0.397 0.016 0.606 0.100
  1. (a)t-test was applied
  2. (b)chi-square test was applied
  3. (c)Mann-Whitney test was applied