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Table 3 Characteristics of surgical and antimicrobial therapy

From: Clindamycin-rifampin combination therapy for staphylococcal periprosthetic joint infections: a retrospective observational study

  Debridement and retention n = 18 n Revision n = 18 n Total n = 36 n
Surgery
 Duration of surgery, minutes; median (range) 34 (18-94) 1 71 (90-290) 91 (18-290)
 Gentamicin beads used 9 (53) -
 Bone impaction grafting - 15 (83)
 Complete / partial revision - 6 (33) / 12 (67)
Antimicrobial therapy
 Prior intravenous antibiotics 12 9 21
 Duration of iv therapy, days; median (range) 11 (2 - 56) 12 (2 - 15) 11 (2-56)
 Duration of iv + oral antibiotic therapy, days; med (range) 101 (31 – 239) 92 (80 – 139) 98 (31-239)
   < 90 days 3 2 5
  Hip PJIa, median (range) 98 (31-146) 92 (80-139) 95 (31-146)
  Knee PJI, median (range) 182 (117-239) -  
Rifampin dose reduction (300 mg twice daily) 3 3 6
Clindamycin-rifampin discontinuation 3 2 5
Due to:
 Comorbidities 2 1 3
Side effects
 Allergy/Rash 2 1 3
 Nausea 2 1 3
 Diarrhea 0 2 2
Treatment outcomes
 Failures 4 1 5
 Successfully treated 14 (78%) 17 (94%) 31 (86%)
 Patients completed clindamycin-rifampin regimen 15 16 31
  ➜ Successfully treated 14 (93%) 15 (94%) 29 (94%)
  1. aPJI, Periprosthetic Joint Infection