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Table 1 Overall sensitivity of the urine LAM using random versus EMU samples, and stratified by diagnostic category and preceding anti-TB treatment

From: Early morning urine collection to improve urinary lateral flow LAM assay sensitivity in hospitalised patients with HIV-TB co-infection

Sensitivity 95% (CI) Manufacturer recommended LF-LAM positive cut point (grade 2) P-value
Random Urine %, 95% CI, n/N Early Morn. Urine %, 95% CI, n/N
Definite- TB only 12 (5–24) (5/41) 39 (26–54) (16/41) 0.005
Probable TB only 9.6 (5–17) 8/82 24 (16–34) 20/82 0.001
Definite and Probable TB combined 10 (6–17) (13/123) 30 (22–38) (36/123) <0.001
No TB Rx prior 11 (4–28) (3/27) 31 (17–50) (8/26) 0.05
TB Rx prior <7 days 10 (2–40) (1/10) 56 (27–81) (5/9) 0.04
No TB Rx prior 15 (8–27) (8/52 25 (15–38) (13/52) 0.1
TB Rx prior < 7 day 0 (0–11) (0/30) 23 (12–41) (7/30) 0.003
No TB Rx prior 14 (8–23) (11/79) 30 (18–38) (21/78) 0.03
TB Rx prior < 7 days 2 (0–12) (1/42) 30 (18–45) (12/40) <0.001