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Table 2 Microbiology and histology results for 20 patients with hepatic tuberculosisa

From: Hepatic tuberculosis in human immunodeficiency virus co-infected adults: a case series of South African adults

Pt Microscopyb and culture of sputum and/or other extrapulmonary site as indicated within () Microbiology of liver tissue Histology of liver tissuea
Culture Sensitivity
1 Smear Negative, Culture Positive for MTB MTB Pansensitive AFB seen with granulomatous inflammation.
2 Smear Negative, Culture Positive for MTB MTB Pansensitive AFB seen. Granulomatous inflammation consistent with TB.
3 Smear Positive for MTB MTB Pansensitive AFB seen. Granulomatous inflammation consistent with TB.
4 Smear Positive for MTB No growth N/A AFB seen. Granulomatous inflammation consistent with TB.
5 Smear Positive for MTB MTB Pansensitive AFB seen. Granulomatous inflammation consistent with TB.
6 Smear Negative, Culture Positive for MTB Not done N/A AFB seen with granulomatous inflammation and features of Schistosomiasis.
7 Smear Positive for MTB MTB Pansensitive AFB seen. Granulomatous inflammation consistent with TB.
8 Smear Positive for MTB No growth N/A AFB seen. Granulomatous inflammation consistent with TB.
9 N/A; (bone marrowc) Not done N/A AFB seen. Granulomatous inflammation consistent with TB. Hepatitis B positived
10 Smear Positive for MTB Not done N/A AFB seen. Granulomatous inflammation consistent with TB.
11 Smear Positive for MTB Not done N/A AFB seen. Granulomatous inflammation consistent with TB.
12 N/A; (AFB positive on blood culture smear) AFB growne Not done AFB seen with granulomatous inflammation.
13 N/A; (cervical lymph nodec; ascitic fluidc) No growth N/A Granulomatous inflammation consistent with TB.
14 Smear Positive for MTB No growth N/A Granulomatous inflammation consistent with TB.
15 Negative; (pleural effusionc) No growth N/A Granulomatous inflammation.
16 N/A No growth N/A Granulomatous inflammation consistent with TB.
17 Smear Positive for MTB Not done N/A AFB seen with granulomatous inflammation.
18 Negative No growth N/A AFB seen. Granulomatous inflammation consistent with TB.
19 Smear Negative, Culture Positive for MTB No growth N/A Features suspicious of Hodgkin’s. Granulomatous inflammation, ZN negative.f
20 Smear Positive for MTB Not done N/A Granulomatous inflammation.
  1. aLiver histology specimens were stained with Ziehl Neelsen stain to detect acid-fast bacilli. Granulomatous inflammation consistent with TB infers caseating granulomas with foci of activated macrophages (epithelioid cells), rimmed by fibroblasts, lymphocytes, histiocytes and occasional multinucleated giant cells [20]. Pt Patient; bAuramine O stain, MTB Mycobacterium Tuberculosis; AFB acid-fast bacilli, TB Tuberculosis, N/A Not applicable; cCulture from this biopsy site was positive for MTB; dImmunohistochemistry positive for Hepatitis B virus surface and core antigen; especies not identified; ZN Ziehl Neelsen; fhistology of bone marrow aspirate showed AFB and granulomatous inflammation consistent with TB