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Table 7 Factors associated with 30-day inpatient mortality in children with Klebsiella pneumoniae bloodstream infection

From: Klebsiella pneumoniae bloodstream infections at a South African children’s hospital 2006–2011, a cross-sectional study

Risk factors for death Alive Died Univariate analysis Adjusted RRa for mortality (n = 259)
n/N (%) n/N (%) RRa (95 % CI) p-value aRR (95 % CI) p-value
ESBL-KPBSI 210/267 (78.7) 100/109 (91.7) 2.36 (1.26–4.43) 0.00 1.09 (0.55–2.16) 0.80
Moderate or severe underweight-for-age 150/267 (56.2) 71/109 (65.1) 1.31 (0.94–1.83) 0.11 1.12 (0.79–1.62) 0.54
HIV-infection** 38/181 (21.0) 37/83 (44.6) 2.03 (1.44–2.85) <0.001 2.44 (1.59–3.74) <0.001
Patient in the PICU at time of BSI** 56/267 (21.7) 31/109 (28.4) 1.28 (0.91–1.80) 0.16 1.64 (1.03–2.61) 0.04
Patient needing to go to PICU at the time of KP bloodstream infection** 44/267 (16.5) 34/109 (31.2) 1.73 (1.26–2.38) 0.001 1.72 (1.10–2.70) 0.02
Continuous IV infusion for >3 days before the BSI 174/264 (65.9) 73/108 (67.6) 1.06 (0.75–1.48) 0.76 0.93 (0.64–1.35) 0.70
BSI without source** 145/266 (54.5) 41/108 (38.0) 0.61 (0.44–0.86) 0.004 0.82 (0.55–1.22) 0.33
Chronic underlying medical condition excluding HIV infection 124/267 (46.4) 41/109 (37.6) 0.77 (0.56–1.07) 0.12 1.30 (0.81–2.08) 0.28
Skin erosions** 70/265 (26.4) 47/108 (43.5) 1.69 (1.24–2.30) 0.001 2.15 (1.54–3.0) <0.001
  1. n/N stratum specific proportions; **p-value ≤ 0.05; RR risk ratio
  2. ESBL KP BSI Extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae bloodstream infection, PICU paediatric intensive care unit, aRR adjusted risk ratio *:Multivariate model adjusted for age, gender, nutrition, HIV infection, ESBL, Patient in PICU, patient needing to go to PICU, continuous IV infusion for >3 days before the BSI, KPBSI without source, chronic underlying medical condition excluding HIV, and skin erosions