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Table 1 Characteristics of the children with Klebsiella pneumoniae bloodstream infection

From: Klebsiella pneumoniae bloodstream infections at a South African children’s hospital 2006–2011, a cross-sectional study

Variable All ESBL-KPb Non-ESBL-KP p value
Number of children (%) N = 410 n = 339/410 (83 %) n = 71/410 (17 %) -
Male: female 212: 198 170: 169 1.77 0.17
Median (IQR) age in months 5 (2–16) 5 (2–5) 10 (2–29) 0.12
Median weight-for-age z-score (IQR) −2 (−4 to −1) −2 (−4 to −1) −1 (−3 to −1) 0.02
Moderate under-weight-for-age n/N (%) 78/410 (19.0) 66/339 (19.5) 12 /71 (16.9) 0.14
Severe underweight-for-age n/N (%) 163/410 (39.8) 143/339 (42.2) 20 /71 (28.2) 0.01
HIV-infectiona (%) (n = 288) (n = 249) (n = 39)  
82 (28.5) 79 (31.7 %) 3 (7.7 %) 0.004
Exposure to a selection of antibioticsc 319/388 (82.2) 287/319 (90) 31/68 (46.4) <0.0001
2nd - 4th generation Cephalosporins 205/388 (52.8) 190/205 (92.8) 15 /69 (17.8) <0.0001
Aminoglycosides 227/388 (58.5) 206/319 (64.6) 21/69 (30.4) <0.0001
Cotrimoxazole 96/388 (24.7) 91/319 (28.5) 5/69 (7.3) 0.001
Carbapenems 69/388 (17.8) 65/319 (20.4) 4 /69 (5.8) 0.004
Piperacillin-tazobactam 107/388 (27.6) 95/319 (29.8) 12/69 (17.4) 0.04
Fluoroquinolones 55/388 (14.2) 48/319 (15.1) 7/69 (10.1) 0.29
  1. KP Klebsiella pneumoniae, IQR interquartile range, n/N stratum specific proportions
  2. aHIV prevalence known in 288 children
  3. bESBL-KP: extended-spectrum-β-lactamase-producing Klebsiella pneumoniae
  4. cExposure to the following antibiotics within the last 12 months before the KP bloodstream infection: 2nd and/or 3rd and/or 4th generation cephalosporins, macrolides, fluoroquinolones, cotrimoxazole, aminoglycosides, piperacillin-tazobactam, and carbapenems