You are viewing the site in preview mode

Skip to main content

Advertisement

Table 5 Multivariate analysis of clinical and laboratory variables as predictors of outcome for fosfomycin treatment of urinary tract infection in adults. Cure and fail are classified according to ‘functional’ definition (results presented in data columns 1–3) or ‘microbiological’ definition (results presented in data columns 4–6)

From: Oral fosfomycin for treatment of urinary tract infection: a retrospective cohort study

Predictor ‘Cure’ (functional definition) Total n = 33 ‘Fail’ (functional definition) Total n = 19 p-value (functional definition) ‘Cure’ (microbiological definition) Total n = 20 ‘Fail’ (microbiological definition) Total n = 19 p-value (microbiological definition)
Fosfomycin resistant in vitro 1/33 1/19 0.21 0/20 1/19 0.99
Klebsiella pneumoniae 2/33 5/19 0.04 2/20 5/19 0.13
Comorbidity (any, including transplant/urethral catheter) 21/33 14/19 0.22 15/20 14/19 0.47
Median eGFR, ml/min (IQR) 64 (41–86) 90 (29–90) 0.19 64 (37–87) 90 (29–90) 0.20
  1. Total number of patients represented is 52 for functional cure (‘cure’ group (n = 33) is patients with a sterile urine on follow-up culture, or no follow-up culture; ‘fail’ group (n = 19) is patients with recurrent growth of an indistinguishable organism)
  2. Total number of patients represented is 39 for microbiological cure (‘cure’ group (n = 20) is patients with a sterile urine on follow-up culture; ‘fail’ group (n = 19) is patients with recurrent growth of an indistinguishable organism)
  3. eGFR estimated glomerular filtration rate