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Table 4 Univariate analysis of clinical and laboratory variables as predictors of outcome for fosfomycin treatment of urinary tract infection in adults. Cure and fail are classified according to ‘functional’ definition (results presented in data columns 1–3) or ‘microbiological’ definition (results presented in data columns 4–6)

From: Oral fosfomycin for treatment of urinary tract infection: a retrospective cohort study

Predictor ‘Cure’ (functional definition) Total n = 42 ‘Fail’ (functional definition) Total n = 19 p-value (functional definition) ‘Cure’ (microbiological definition) Total n = 21 ‘Fail’ (microbiological definition) Total n = 19 p-value (microbiological definition)
ESBL-positive 20/37 10/19 1.0a 12/21 10/19 1a
Nitrofurantoin resistant 17/37 12/19 0.3a 8/21 12/19 0.2a
Fosfomycin resistant 1/35 1/19 1.0a 0/20 1/19 0.49a
Male 14/42 4/19 0.4a 4/21 4/19 0.72a
Klebsiella pneumoniae 2/37 5/19 0.03a 2/21 5/19 0.22a
Comorbidity (any) 32/42 15/19 1.0a 12/21 15/19 0.19a
Transplant 8/42 3/19 1.0a 4/21 3/19 1a
Urethral catheter 4/42 3/19 0.66a 2/21 3/19 0.65a
Median age, years (IQR) 75 (62–81) 64 (42–79) 0.13b 70 (58–78) 64 (42–79) 0.47b
Median eGFR, ml/min (IQR) 70 (41–87) >90 (29– > 90) 0.2b 64 (38–89) >90 (29– > 90) 0.26b
Median CRP, mg/L (IQR) 21 (3–93) 25 (6–62) 1.0b 16 (2–78) 25 (6–62) 0.84b
  1. Total number of patients represented is 61 for functional cure (‘cure’ group (n = 42) is patients with a sterile urine on follow-up culture, or no follow-up culture; ‘fail’ group (n = 19) is patients with recurrent growth of an indistinguishable organism). Total number of patients is 40 for microbiological cure (‘cure’ group (n = 21) is patients with a sterile urine on follow-up culture; ‘fail’ group (n = 19) is patients with recurrent growth of an indistinguishable organism)
  2. The denominator in some rows is smaller than the overall total due to missing data, including no culture / susceptibility data and ESBL-status unknown or not applicable
  3. eGFR estimated glomerular filtration rate, CRP C-reactive protein
  4. aFisher’s Exact Test; b Mann Whitney U test