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Table 3 Summary of five patients treated with more than ten 3 g doses of oral fosfomycin for UTI

From: Oral fosfomycin for treatment of urinary tract infection: a retrospective cohort study

Study number Age group at first dose (years) Gender Clinical background, including possible risk factors for UTI Urine culture result Total number of 3 g fosfomycin doses eGFR at baseline Any reported side-effects Notes on outcome
FOS015 80–89 M Vasculopath; bilateral below knee amputations. Recurrent E. coli bacteraemia with unclear source despite extensive investigation. Relapsed after a treatment course of iv ertapenem ESBL E. coli 36 79 None reported Well when reviewed following end of treatment course; discharged from clinic
FOS038 60–69 M History of recurrent UTI for > 10 years. Dilatation for urethral stricture, followed by TURP. Prostate cancer confirmed; treated post-op with radiotherapy ESBL E. coli 81 >90 None reported Interval free of infection, followed by recurrence of UTI (different organisms)
FOS060 60–69 M Relapsing urosepsis following TRUS biopsy (negative for prostate cancer). Presumed prostatitis as focus of infection. ESBL E. coli 33 79 Reported shortness of breath during treatment, but thought unlikely to be related to fosfomycin Well when reviewed following end of treatment course; discharged from clinic
FOS098 70–79 M Transitional cell carcinoma treated with nephrouretectomy. Regular surveillance cystoscopy complicated by recurrent UTI; recurred after completing treatment with meropenem. ESBL E. coli 49 41 None reported Interval free of infection, followed by recurrence and re-treatment with fosfomycin
FOS140 40–49 F Recurrent UTI following sling procedure and botox treatment for stress/urge incontinence. Intermittent self-catheterisation. Good symptomatic relief with fosfomycin. E. coli 15 >90 None reported Ongoing prophylaxis while awaiting urogynaecology surgery
  1. eGFR estimated glomerular filtration rate, TURP trans-urethral resection of the prostate, TRUS trans-rectal ultrasound guided prostate biopsy