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Table 1 Literature reports of CNS infections caused by Mycoplasma hominis in non-neonatal patients (1950-2016.7)

From: Meningitis in a Chinese adult patient caused by Mycoplasma hominis: a rare infection and literature review

No. Author & year Pt age(years), sex Pt Country HU Tr SI Clinical manifestation Days to Dx after Ad Dx basis Antibiotics used prior to diagnosis Final antibiotic regimen Otc Ref
1 Paine et al. [14] 20, M USA N Y Y fever, headache, a stiff neck 18 C S + P + St Sm CR [14]
2 Payan et al. [15] 29, M USA Y Y Y fever, loss of consciousness 23 C O + Cp + N + C T + E CR [15]
3 Madoff S et al. [16] 11, F USA N N Y fever 26 GIT + IRT V + E Mc De [16]
4 McMahon et al. [24] 76, M USA N N Y fever, unresponsive 18 C P + G none De [24]
5 Kersten RC et al. [17] 20, M USA Y Y Y fever, comatose 19 C A + M + Su + V + Cf M + Cf + Az + Am + Cl Re [17]
        NM 35 C Az + Am + Cl M + Cf + D + Cd CR [17]
6 Cohen & Kubak. [25] 18, F USA N Y Y fever, altered mental status 20 C E D + Ci + C CR [25]
7 Zheng et al. [18] 22, F USA N N Y fever, left-sided weakness and numbness 18 IRT + IBA Ct + N + Ca + M none CR [19]
8 Douglas et al. [19] 17, F Australia N Y Y fever, headache, photophobia, nausea, vomiting 13 C + 16S A + Ca + E D + Cd CR [19]
9 House P et al. [20] 40, F Spain N N Y headache, left facial weakness, nausea, afebrile 12 + “several” C + 16S V + Cf + M Ci + M CR [20]
10 Kupila L et al. [21] 40, M Finland N Y Y haematuria and urine retention, confused 14 16S none T CR [21]
11 McCarthy & Looke. [3] 48, M Australia N N Y fever 36 C + 16S Cz + V Ga + Cd CR [3]
12 McCarthy & Looke. [3] 17, F Australia N Y Y fever 17 C V + Me Ga + Mo CR [3]
13 Al Masalma et al. [22] 41, F Russia N N Y vertigo, coma headache, hemiparesis 10 16S V + Me D CR [22]
14 Lee et al. [8] 48, F Netherlands Y Y Y fever 15 16S F + V Mo CR [8]
15 Henao-Martínez et al. [10] 40, M Somalia N Y Y fever 17 C + 16S V + PT + Ct + M D CR [10]
16 Pailhorie ‘s et al. [23] 43, M France N Y Y fever, delirium tremens 13 Vitek MS + 16S Me + V + Fo L + D CR [23]
17 Whitson WJ [2] 17, M USA Y Y Y fever, bicep and deltoid weakness 32 C PT + V + Ct + M D + Mo CR [2]
18 Hos NJ [27] 21, F Germany N N Y fever, neck pain, nausea, vomiting, 31 C + 16S A + Ct Mo CR [27]
19 Reissier S [26] 39, M France N Y Y afbrile, loss of consciousness 33 C + 16S + RT-PCR PT + Li + Ct + Me + V Mo De [26]
20 Present study 79, M China N N Y fever, anepia and right-sided weakness 17 16S Me + V + CF Az + D + Mi CR  
  1. Ad admitted, C culture, CR clinical recovery, De death, Dx diagnosis, GIT growth inhibition test, HU hormone use, IBA immunoblot assay, IRT immunofluo-rescence test, Otc outcome, Re recurrence, Ref reference, SI surgical intervention, 16S 16S rDNA sequencing, RT-PCR real-time PCR, Tr trauma, yrs: years
  2. Ampicillin, (A) amoxicillin, (Am) azithromycin, (Az) chloramphenicol, (C) cefazolin, (Ca) clindamycin, (Cd) cefotaxime, (Cf) ciprofloxacin, (Ci) clavulanate potassium, (Cl) cephalothin (Cp), ceftriaxone (Ct), ceftazidime (Cz), cefoperazone/ sulbactam (CF), doxycycline (D), erythromycin (E),flucloxacillin (F), fosfomycin (Fo),gentamicin (G), gatifloxacin (Ga),levofloxacin (L), linezolid (Li), metronidazole (M), methacycline (Mc), meropenem (Me), minocyline (Mi), moxifloxacin (Mo),nafcillin (N), oxacillin (O),penicillin (P), piperacillin/tazobactam (PT), sulfadiazine (S), streptomycin (Sm), sulfathiazole (St), sulbactam (Su), tetracycline (T), vancomycin (V)