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Table 4 Patient knowledge about Hepatitis C and its treatment, prior and after the health educational program

From: A multidimensional education program at substance dependence treatment centers improves patient knowledge and hepatitis C care

  Baseline Post-HEP p value
Overall knowledge score, %a    <0.001
 mean ± SD 68.8 ± 16.6 79.0 ± 12.4
 median (min-max) 71.8 (7.7–98.3) 81.2 (15.4–100)
Disease knowledge sub-score, %a    <0.001
 mean ± SD 71.6 ± 16.4 79.9 ± 13.1
 median (min-max) 74.1 (11.1–100) 81.4 (11.1–100)
Questions
1. Patient shows symptoms immediately after infection with HCV
 No, % (n) [correct] 78.0 (393) 88.9 (448) <0.001
2. If left untreated, the majority of cases progress to cirrhosis
 Yes, % (n) [correct] 77.2 (389) 86.1 (434) <0.001
3. Co-infection with HIV may increase disease progression
 Yes, % (n) [correct] 78.8 (397) 86.7 (437) <0.001
4. Alcohol consumption may increase disease progression
 Yes, % (n) [correct] 96.8 (488) 98.8 (498) <0.001
5. What is HCV disease, % (n)
 Is a liver viral disease [correct] 91.5 (461) 96.4 (486) <0.001
 Is a disease that affects whole body organs 3.0 (15) 2.2 (11)  
 Doesn’t know 5.6 (28) 1.4 (7)  
6. How is HCV transmitted, % (n)b
 Sexual transmission only 4.8 (24) 2.6 (13) 0.061
 Sexual and blood transmission [correct] 73.9 (370) 84.3 (425) 0.001
 Physical contact 4.6 (23) 3.0 (15) 0.134
 Sharing of materials related with drug use 15.6 (78) 10.1 (51) 0.004
 Doesn’t know 5.2 (26) 1.4 (7) <0.001
 Other 2.8 (14) 1.4 (7)  
7. What are the symptoms of HCV disease, % (n)c
 Generalized weakness [correct] 38.7 (195) 41.7 (210) 0.295
 Weight loss [correct] 19.2 (97) 23.8 (120) 0.062
 Vomits and diarrhea [correct] 10.3 (52) 13.3 (67) 0.142
 All the previous [correct] 19.4 (98) 20.6 (104) 0.659
 There are no symptoms 14.5 (73) 16.9 (85) 0.261
 Doesn’t know 21.2 (107) 14.5 (73) 0.001
8. HCV disease is curable
 Yes, % (n) [correct] 74.2 (373) 88.7 (447) <0.001
9. Which diseases are most associated with HCV disease?, % (n)c
 HIV 20.2 (102) 31.7 (160) <0.001
 Hepatitis B 25.4 (128) 27.6 (139) 0.396
 Tuberculosis 8.7 (44) 10.3 (52) 0.403
 All the previous [correct] 17.1 (86) 20.0 (101) 0.199
 Doesn’t know 42.3 (213) 30.2 (152) <0.001
HCV treatment knowledge sub-score, %a
 mean ± SD 62.4 ± 26.9 % 76.8 ± 18.3 % <0.001
 median (min-max) 69.4 (0.0–100) 80.6 (0.0–100)
Questions
10. What are the treatment options for HCV disease, % (n)    <0.001
 Treatment that should be used over the lifetime 3.6 (18) 1.8 (9)  
 Treatment that should be used during a limited period [correct] 82.7 (417) 92.7 (467)  
 There is no treatment 1.8 (9) 0.4 (2)  
 Doesn’t know 11.9 (60) 5.2 (26)  
11. What are the possible treatment outcomes, % (n)    <0.001
 Most patients develop liver cirrhosis 5.0 (25) 2.2 (11)  
 Most patients become cured [correct] 66.7 (335) 86.1 (434)  
 Doesn’t know 28.3 (142) 11.7 (59)  
12. What are main adverse reactions to HCV treatment, % (n)d    
 Flu-like symptoms [correct] 35.3 (178) 45.8 (231) <0.001
 Fatigue [correct] 53.0 (267) 65.3 (329) <0.001
 Depression [correct] 36.7 (185) 50.8 (256) <0.001
 Appetite loss [correct] 42.3 (213) 54.0 (272) <0.001
 Nausea, vomits and diarrhea [correct] 33.7 (170) 44.8 (226) <0.001
 Skin reactions [correct] 15.5 (78) 27.2 (137) <0.001
 Weight loss [correct] 40.7 (205) 60.3 (304) <0.001
 Alopecia [correct] 21.4 (108) 32.1 (162) <0.001
 Doesn’t know 31.0 (156) 6.2 (31) <0.001
 Other 6.0 (30) 16.1 (81)  
13. Do adverse reactions disappear after treatment discontinuation
 Yes, % (n) [correct] 68.8 (346) 85.5 (431) <0.001
  1. McNemar test was used to compare changes in the proportion of correct answers for each question between baseline and after program implementation. Wilcoxon test was used to analyze changes in overall knowledge score and sub-scores between both time points. p < 0.05 is considered statistically significant
  2. HEP Health Educational Program, SD standard-deviation
  3. aThe overall knowledge score was calculated by assigning one point to each correct answer. The score reflected the percentage of points obtained out of the 13 questions. For all questions, missing data and “don’t know” answers were considered as not correct (score = 0). Disease knowledge sub-score was calculated based on correct answers to questions 1–9. HCV treatment knowledge sub-score was calculated based on correct answers to questions 10–13
  4. bWhenever a patient chose more options than the correct one, a score of “1/number of answers” was attributed
  5. cWhenever a patient chose one or two out of three correct options a score of 0.33 and 0.67 was attributed, respectively
  6. dThe score was the number of correct answers over nine questions