- Case report
- Open Access
- Open Peer Review
Multiple systemic embolism in infective endocarditis underlying in Barlow’s disease
- Ziqing Yu†1, 2,
- Bing Fan†1,
- Hongyi Wu1,
- Xiangfei Wang1,
- Chenguang Li1,
- Rende Xu1,
- Yangang Su1Email author and
- Junbo Ge1Email author
© The Author(s). 2016
- Received: 6 August 2015
- Accepted: 20 July 2016
- Published: 11 August 2016
Systemic embolism, especially septic embolism, is a severe complication of infective endocarditis (IE). However, concurrent embolism to the brain, coronary arteries, and spleen is very rare. Because of the risk of hemorrhage or visceral rupture, anticoagulants are recommended only if an indication is present, e.g. prosthetic valve. Antiplatelet therapy in IE is controversial, but theoretically, this therapy has the potential to prevent and treat thrombosis and embolism in IE. Unfortunately, clinical trial results have been inconclusive.
We describe a previously healthy 50-year-old man who presented with dysarthria secondary to bacterial endocarditis with multiple cerebral, coronary, splenic, and peripheral emboli; antibiotic therapy contributed to the multiple emboli. Emergency splenectomy was performed, with subsequent mitral valve repair. Pathological examination confirmed mucoid degeneration and mitral valve prolapse (Barlow’s disease) as the underlying etiology of the endocardial lesion. Continuous antibiotics were prescribed, postoperatively. Transthoracic echocardiography at 1.5, 3, and 6 months after the onset of his illness showed no severe regurgitation, and there was no respiratory distress, fever, or lethargy during follow-up.
Although antibiotic use in IE carries a risk of septic embolism, these drugs have bactericidal and antithrombotic benefits. It is important to consider that negative blood culture and symptom resolution do not confirm complete elimination of bacteria. However, vegetation size and Staphylococcus aureus infection accurately predict embolization. It is also important to consider that bacteria can be segregated from the microbicide when embedded in platelets and fibrin. Therefore, antimicrobial therapy with concurrent antiplatelet therapy should be considered carefully.
- Infective endocarditis
- Antiplatelet treatment
Systemic embolism, particularly septic embolism, is a severe complication of IE. However, concurrent embolism to the brain, coronary arteries, and spleen is very rare. Because of the risk of hemorrhage or visceral rupture, anticoagulants are recommended only if an indication for anticoagulation is present , e.g. prosthetic valve. Also, antiplatelet therapy in IE remains controversial, with available clinical trials and animal experiments providing contradictory results. Theoretically, antiplatelet therapy has the potential to inhibit and treat thrombosis and embolism in IE. Unfortunately, the results of clinical trials are inconclusive.
We described here an IE case with multiple systemic embolism in infective endocarditis underlying in Barlow's disease. Although antibiotic use in IE carries a risk of septic embolism, these drugs have bactericidal and antithrombotic benefits. It is important to consider that negative blood culture and symptom resolution do not confirm complete elimination of bacteria. However, vegetation size and Staphylococcus aureus infection accurately predict embolization. It is also important to consider that bacteria can be segregated from the microbicide when embedded in platelets and fibrin. Therefore, antimicrobial therapy with concurrent antiplatelet therapy should be considered carefully.
We report a unique IE case complicated by concurrent cerebral infarction, acute myocardial infarction, and splenic rupture. To our knowledge, a similar case has not been reported previously. In a retrospective study of IE, 499 of 1456 patients (34 %) were complicated by embolic events. Prosthetic valve location, right-sided endocarditis, Staphylococcus aureus infection, and vegetation size are considered high risk factors for embolism . In prospective cohorts, embolic events occurred in 34.1 % , and 46 %  of patients, and age, sex, serum creatinine, and C-reactive protein levels were considered additional risk factors. In other studies , the incidence of embolism was 8.5 %, and a formula was developed to determine the likelihood of embolism, considering age, diabetes, atrial fibrillation, embolism before antibiotics, vegetation size, and Staphylococcus aureus infection. Results showed that vegetation size and Staphylococcus aureus infection validly predict embolization. In septic embolism, antibiotics have dual effects including bactericidal and antithrombotic effects. However, systemic embolism tends to take place in patients with embolism before antibiotic treatment, increasing vegetation size in spite of antimicrobial therapy, when Staphylococcus spp are involved in the mitral valve vegetation . Also, antibiotic regimes should be chosen carefully because different antibiotics have different effects on IE. One clinical study revealed that vancomycin and ampicillin were associated with significant reduction in vegetation size; however, cephalosporin and penicillinase-resistant drugs were associated with increased vegetation size and embolic risk . Unfortunately, negative blood culture and resolution of clinical signs do not confirm bacterial elimination. One reason may be drug resistance, and another may be that antibiotics cannot access the center of the vegetation. The vegetation consists of platelets, fibrin, bacteria, and other components, and bacteria are segregated from endogenous microbicides such as some proteins, and exogenous antibiotics, by the platelets and fibrin. The outer crust of the vegetation envelops and confines the bacteria to prevent dissemination, but this protects bacteria from being thoroughly eliminated [9, 10]. It is not currently known which antibiotics perform better regarding anti-thrombosis; therefore, the best future antibiotics will have both good bactericidal effects, and good penetration into the vegetation. Currently, careful consideration should be given to whether concurrent antimicrobial therapy and antiplatelet therapy is more beneficial than antibiotics alone. In vitro, platelet aggregation can be antagonized by aspirin in the presence of bacteria isolated from blood culture . In vivo animal experiments have shown that aspirin has antibacterial effects in IE, inhibiting bacterial adhesion to platelets and vegetation . Aspirin has a dose-dependent effect on reducing vegetation size, with the greatest benefit at middle doses. This is perhaps because lower doses of aspirin do not completely inhibit platelets, while higher doses also decrease prostacyclin, which inhibits platelet aggregation. Regarding antiplatelet effects, aspirin and ticlopidine equally reduce vegetation.
Antiplatelet therapy can dramatically diminish vegetation, when used with vancomycin. However, clinical trials have shown contradictory effects of antiplatelet therapy. Some researchers argue that aspirin reduces stroke events, the number of patients requiring surgery, or mortality, without increasing hemorrhagic events [13–15]; however, these studies were retrospective, and included small sample sizes. A prospective randomized controlled trial showed that aspirin failed to reduce the risk of embolism . Because the cyclooxygenase pathway is not the only way to activate platelets, especially in endocarditis, the activator may not be derived from thromboxane A2; therefore, aspirin, which inhibits cyclooxygenase to reduce thromboxane A2, may play a less important role in IE. This theory may explain why aspirin performed poorly in a prospective trial, and thus, the need for more research regarding other antiplatelet drugs with mechanisms different from aspirin, such as clopidogrel, cilostazol, and ticagrelor, in preventing and treating embolism in IE. Considering the findings in current studies, antiplatelet therapy has potential in IE therapy.
AMI, acute myocardial infarction; CK, creatine kinase; IE, infective endocarditis; LVEDD, left ventricular end-diastolic dimension; LVESD, left ventricular end-systolic dimension; NT-pro-BNP, N-Terminal-pro-Brain natriuretic peptide; TXA2, thromboxane A2
We would like to sincerely thank Heart Surgery Department of Zhongshan Hospital. Besides, the work was supported by grants from the Shanghai Municipal Commission of Health & Family Planning: Key Discipline (No. 12411952202) and Zhongshan hospital science fund (No. fund-044).
Shanghai Municipal Commission of Health & Family Planning: Key Discipline (No. 12411952202) and Zhongshan hospital science fund (No. fund-044).
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All data cotnained within this article.
ZY participated in acquisition of data and drafting the the initial and final manuscript; BF took part in clinical data acquisition and literature retrieval; XW, and HW took part in acquisition of clinical data; CL and RX carried out acquisition of laboratory data; YS participated in acquisition data, having given final approval of the version to be published; JG wrote response letter to reviewer and gave final approval of the version to be published. All authors read and approved the final manuscript.
The authors declare that they have no competing interests.
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- Whitlock RP, Sun JC, Fremes SE, Rubens FD, Teoh KH. Antithrombotic and thrombolytic therapy for valvular disease: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012;141:e576S–600S.View ArticlePubMed CentralGoogle Scholar
- Manzano MC, Vilacosta I, San RJ, Aragoncillo P, Sarria C, Lopez D, et al. Acute coronary syndrome in infective endocarditis. Rev Esp Cardiol. 2007;60:24–31.View ArticleGoogle Scholar
- Rizzi M, Ravasio V, Carobbio A, et al. Predicting the occurrence of embolic events: an analysis of 1456 episodes of infective endocarditis from the Italian Study on Endocarditis (SEI)[J]. BMC Infect Dis. 2014;14:230.View ArticlePubMed CentralGoogle Scholar
- Thuny F, Di Salvo G, Belliard O, et al. Risk of embolism and death in infective endocarditis: prognostic value of echocardiography: a prospective multicenter study[J]. Circulation. 2005;112(1):69–75.View ArticleGoogle Scholar
- Durante ME, Adinolfi LE, Tripodi MF, et al. Risk factors for “major” embolic events in hospitalized patients with infective endocarditis[J]. Am Heart J. 2003;146(2):311–6.View ArticleGoogle Scholar
- Hubert S, Thuny F, Resseguier N, et al. Prediction of symptomatic embolism in infective endocarditis: construction and validation of a risk calculator in a multicenter cohort[J]. J Am Coll Cardiol. 2013;62(15):1384–92.View ArticleGoogle Scholar
- Vilacosta I, Graupner C, San RJ, et al. Risk of embolization after institution of antibiotic therapy for infective endocarditis[J]. J Am Coll Cardiol. 2002;39(9):1489–95.View ArticleGoogle Scholar
- Rohmann S, Erhel R, Darius H, et al. Effect of antibiotic treatment on vegetation size and complication rate in infective endocarditis[J]. Clin Cardiol. 1997;20(2):132–40.View ArticleGoogle Scholar
- McColm AA, Ryan DM. Penetration of beta-lactam antibiotics into cardiac vegetations, aorta and heart muscle in experimental Staphylococcus aureus endocarditis: comparison of ceftazidime, cefuroxime and methicillin. J Antimicrob Chemother. 1985;16:349–58.View ArticleGoogle Scholar
- Eng RH, Parken P, Tecson-Tumang F. Penetration of antibiotics into vegetation of heart valves: a mathematical model. Chemotherapy. 1982;28:421–7.View ArticleGoogle Scholar
- Kessler CM, Nussbaum E, Tuazon CU. In vitro correlation of platelet aggregation with occurrence of disseminated intravascular coagulation and subacute bacterial endocarditis. J Lab Clin Med. 1987;109:647–52.Google Scholar
- Kupferwasser LI, Yeaman MR, Shapiro SM, Nast CC, Sullam PM, Filler SG, et al. Acetylsalicylic acid reduces vegetation bacterial density, hematogenous bacterial dissemination, and frequency of embolic events in experimental Staphylococcus aureus endocarditis through antiplatelet and antibacterial effects. Circulation. 1999;99:2791–7.View ArticleGoogle Scholar
- Pepin J, Tremblay V, Bechard D, Rodier F, Walker C, Dufresne D, et al. Chronic antiplatelet therapy and mortality among patients with infective endocarditis. Clin Microbiol Infect. 2009;15:193–9.View ArticleGoogle Scholar
- Taha TH, Durrant SS, Mazeika PK, Nihoyannopoulos P, Oakley CM. Aspirin to prevent growth of vegetations and cerebral emboli in infective endocarditis. J Intern Med. 1992;231:543–6.View ArticleGoogle Scholar
- Eisen DP, Corey GR, McBryde ES, Fowler VJ, Miro JM, Cabell CH, et al. Reduced valve replacement surgery and complication rate in Staphylococcus aureus endocarditis patients receiving acetyl-salicylic acid. J Infect. 2009;58:332–8.View ArticleGoogle Scholar
- Connolly DL, Choudhury A, Davis RC, Lip GY. A randomized trial of aspirin on the risk of embolic events in patients with infective endocarditis. J Am Coll Cardiol. 2004;43:1134–5.View ArticleGoogle Scholar