You are viewing the site in preview mode

Skip to main content

Advertisement

Table 2 Adverse events potentially related to the daptomycin-based antimicrobial therapy (n = 43) that occurred in 17 of the 43 included patients. Daptomycin dose is expressed in mg/kg/d. AEs onsets are notified in days

From: Daptomycin > 6 mg/kg/day as salvage therapy in patients with complex bone and joint infection: cohort study in a regional reference center

Adverse events n (%) Daptomycin dose (mean, range) AE onset (mean, range) Daptomycin withdrawal Companion drug withdrawal
Hematologic disorders 12 (28) 7,8 (7–9) 44 (7–92) 4/12 3/12
 Hypereosinophilia 6 (14) 7,8 (7–9) 43 (10–92) 3/6 1/6
 Neutropenia 4 (9) 7,8 (7–9) 73 (49–88) 1/4 2/4
Increased blood CPK 4 (9) 7,5 (7–8) 49 (9–92) 2/4 2/4
PICC thrombosis 3 (7) 8,3 (7–9) 39 (12–79) 1/3 0/3
Hepatic disorders 3 (7) 8,2 (7,5–9) 71 (13–112) 0/3 1/3
Eosinophilic pneumonia 2 (5) 8,5 (8–9) 17 (6–23) 2/2 1/1
Increased blood creatinine 1 (2) 8 8 1 1
Pancreatitis 1 (2) 8 180 0 1
  1. AE, Adverse event, CK, Creatine kinase, PICC, Peripherally inserted central catheter