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Table 1 Demographic characteristics of 43 patients who received daptomycin-based antimicrobial therapy

From: Daptomycin > 6 mg/kg/day as salvage therapy in patients with complex bone and joint infection: cohort study in a regional reference center

Characteristic (n, %)
Gender  
 Female 18 (42)
 Male 25 (58)
Mean age, years (range) 61 (18–88)
Age groups  
  < 65 years 25 (58)
  ≥ 65–< 75 years 8 (19)
  ≥ 75 years 10 (23)
Mean body weight, kg (range) 75 (32–110)
Mean body mass index (range) 27 (14–43)
BMI ≥ 25, < 30 9 (21)
BMI ≥ 30 14 (33)
Ethnicity (caucasian) 42 (98)
Active smoking 10 (23)
Underlying diseases  
 Hypertension 17 (40)
 Diabetes mellitus 5 (12)
 Cardiovascular disease 13 (30)
 Cancer 6 (14)
 Creatinine clearance (MDRD) 30–60 mL/min 3 (7)
 Immunosuppression 4 (9)
Mean ASA score (range) 2.2 (1–4)
Past episode of BJI on the same site 27 (63)
Anatomical site of infection  
 Knee 12 (28)
 Hip 9 (21)
 Lower limb 9 (21)
 Rachis 8 (19)
 Upper limb 2 (5)
 Other 1 (2)
Chronic osteomyelitis 37 (86)
Physiopathology of osteomyelitis  
 Post-operative 41 (95)
 Hematogenous infection 2 (5)
 Pressure ulcer 2 (5)
Orthopedic device  
 Prosthesis 23 (53)
 Osteosynthesis device 14 (33)
 None 6 (14)
Previous exposition to antimicrobials for the index BJI before daptomycin prescription  
 Glycopeptides 37 (86)
 Fluoroquinolones 27 (63)
 Rifampin 25 (58)
 Clindamycin, pristinamycin 18 (42)
 Piperacillin tazobactam 15 (35)
 Cephalosporins 13 (30)
 Fosfomycin 13 (30)
 Oxacillin, cloxacillin 12 (28)
 Aminoglycosids 9 (21)
 Fucidic acid 7 (16)
 Linezolid 5 (12)
 Others 18 (42)
  1. Data are n (%) unless otherwise indicated
  2. ASA American Society of Anesthesiologists, BJI Bone and joint infection, BMI Body mass index, MDRD Modification of the diet in renal disease