You are viewing the site in preview mode

Skip to main content

Advertisement

Table 2 Empirical antibiotic therapy and therapeutic responses in children with urinary tract infection caused by E. coli or K. pneumoniae

From: Aminoglycoside therapy for childhood urinary tract infection due to extended-spectrum β-lactamase-producing Escherichia coli or Klebsiella pneumoniae

Factor Non-ESBL group ESBL group p-value
(n = 189) (n = 22)
Administered empirical antibiotics    0.814
With aminoglycoside    
Third-generation cephalosporin + aminoglycoside 111 (58.7) 13 (59.1)  
Aminopenicillin/β-lactamase inhibitor + aminoglycoside 34 (18.0) 4 (18.2)  
Second-generation cephalosporin + aminoglycoside 4 (2.1) 1 (4.5)  
Without aminoglycoside    
Third-generation cephalosporin 25 (13.2) 3 (13.6)  
Aminopenicillin/β-lactamase inhibitor 2 (1.1) 1 (4.5)  
Second-generation cephalosporin 1 (0.5) 0 (0.0)  
Others 10 (5.3) 0 (0.0)  
No therapy 2 (1.1) 0 (0.0)  
Appropriateness of empirical antibiotic therapya 182 (100.0) 20 (90.9) 0.011
Antibiotic duration (days)    
Total 13.0 (12.0–14.0) 14.0 (13.0–16.0) 0.048
Intravenousb 6.0 (5.0–7.0) 6.0 (5.0–7.0) 0.742
Oralc 7.0 (7.0–9.0) 7.0 (6.0–10.5) 0.477
Aminoglycosidesd 6.0 (4.0–7.0) 6.0 (5.0–7.0) 0.170
Fever duration after antibiotic therapy (days)e 1.0 (0.0–2.0) 1.0 (0.0–1.3) 0.573
Response to empirical antibiotic therapy    
Disappearance of fevere 172 (92.5) 20 (90.9) 0.680
Bacterial eradication on the urinef 174 (98.9) 21 (100.0) 1.000
Follow-up time of urine culture (days)f 2.0 (2.0–3.0) 2.0 (1.0–2.5) 0.611
  1. Data are median (interquartile range) or no. (%) of cases
  2. ESBL extended-spectrum β-lactamase
  3. aThe appropriateness of empirical antibiotic therapy was determined in 204 children (182 in the non-ESBL group, 22 in the ESBL group)
  4. bEleven children of the non-ESBL group, who did not received antibiotic therapy or received exclusively oral antibiotic therapy, were excluded
  5. cSix children, who received exclusively intravenous antibiotic therapy, were excluded (Five in the non-ESBL group, One in the ESBL group)
  6. dThe duration of aminoglycoside therapy was determined in 167 children (149 in the non-ESBL group, 18 in the ESBL group)
  7. eThe accurate time of defervescence was not determined in three children in the non-ESBL group, who was lost to follow-up in the outpatient clinic
  8. fMicrobiological response to first line antibiotics was determined in 197 children (176 in the non-ESBL group and 21 in the ESBL group) in whom repeated urine cultures were performed before antibiotic change