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Table 4 Multi locus sequence types of serotype 15A (n = 20) and serotype 23B (n = 21) isolates, with their year of isolation and MIC towards penicillin

From: Increase of serotypes 15A and 23B in IPD in Germany in the PCV13 vaccination era

serotype MLST CC aroE gdh gki recP Spi xpt ddl n= years MIC PEN
23B 439 439 1 8 9 2 6 4 6 7 1994,1998, 2001, 2007, 2008, 2009, 2010 0.015 (n = 7)
23B 9867 439 1 4 388 2 6 4 6 3 2012, 2013, 2014 0.015 (n = 3)
23B 9872 439 1 8 421 2 6 4 6 1 2003 0.015
23B 778 439 1 8 9 1 6 1 6 1 2006 0.015
23B 1349 338 18 13 8 6 3 6 8 6 1997, 2001, 2004, 2009, 2010, 2012 0.06; 0.12; 0.25 (n = 3); 0.5
23B 2372 338 18 13 8 6 3 6 46 3 2008, 2011 (n = 2) 0.015; 0.12; 0.25
15A 63 63 2 5 36 12 17 21 14 5 1998, 2001, 2006, 2008, 2009 0.06; 0.12 (n = 2); 0.25; 0.5
15A 2105 63 2 5 36 12 17 21 4 2 2010, 2013 1 (n = 2)
15A 2613 63 2 5 36 12 17 1 4 1 2013 2
15A 9874 63 2 5 422 12 17 21 14 1 2004 0.25
15A 3811 156 7 11 10 1 6 8 315 2 2013, 2014 0.015 (n = 2)
15A 9868 156 7 33 1 1 6 31 14 1 1999 0.015
15A 473 473 7 25 4 4 15 20 28 1 2002 0.015
15A 9873 473 7 25 4 4 15 20 623 1 2011 0.015
15A 410 193 8 10 2 16 7 26 1 1 2009 0.015
15A 199 199 8 13 14 4 17 4 14 1 2005 0.015
15A 1576 292 10 8 8 8 6 28 14 1 1998 0.12
15A 9308 group of three 15 5 15 1 398 1 18 1 2004 0.015
15A 9871 singleton 7 424 8 8 6 570 14 1 2012 0.015
15A 1577 singleton 10 13 67 16 6 1 8 1 1999 0.25
  1. CC: clonal complex.
  2. MLST in bold are new sequence types found for the first time in this study.