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Table 3 Ranking of penicillin non-susceptible (MIC >0.06 μg/ml) isolates from IPD among children and adults in Germany before childhood vaccination (1992-2006) and after PCV7 (2006) and PCV10/PCV13 (2009) vaccination

From: Increase of serotypes 15A and 23B in IPD in Germany in the PCV13 vaccination era

PenNS rank 1992-2006 n= % 2006-2007 n= % 2007-2008 n= % 2008-2009 n= % 2009-2010 n= % 2010-2011 n= % 2011-2012 n= % 2012-2013 n= % 2013-2014 n= %
1 14 66 19.7 14 21 23.3 19A 33 28.4 19A 50 36.0 19A 71 46.7 19A 92 48.2 19A 67 36.8 19A 54 27.4 15A 39 23.8
2 6B 52 15.5 19A 20 22.2 14 28 24.1 19F 19 13.7 19F 15 9.9 15A 18 9.4 23B 32 17.6 15A 40 20.3 23B 39 23.8
3 9V 45 13.4 19F 13 14.4 9V 15 12.9 6B 12 8.6 23B 13 8.6 19F 16 8.4 15A 27 14.8 23B 38 19.3 19A 28 17.1
4 19A 43 12.8 23F 12 13.3 23F 8 6.9 14 10 7.2 6B 10 6.6 23B 16 8.4 14 11 6.0 14 12 6.1 14 7 4.3
5 23F 40 11.9 9V 10 11.1 6B 8 6.9 23F 6 4.3 15A 9 5.9 9V 8 4.2 6A 7 3.8 19F 6 3.0 6B 6 3.7
6 19F 31 9.3 6B 5 5.6 19F 6 5.2 15A 5 3.6 14 6 3.9 14 5 2.6 19F 6 3.3 11A 5 2.5 6C 6 3.7
7 15A 7 2.1 6A 4 4.4 1 2 1.7 23B 5 3.6 9V 5 3.3 23F 5 2.6 6C 6 3.3 17F 4 2.0 24F 5 3.0
8 9A 7 2.1 24F 2 2.2 34 2 1.7 9V 5 3.6 23F 4 2.6 6B 4 2.1 6B 4 2.2 23F 4 2.0 35B 5 3.0
9 6A 5 1.5 15C 1 1.1 15A 2 1.7 18C 3 2.2 6A 4 2.6 17F 3 1.6 12F 3 1.6 24F 4 2.0 12F 4 2.4
10 4 4 1.2 35F 1 1.1 24F 2 1.7 6A 3 2.2 35B 3 2.0 22F 3 1.6 15B 3 1.6 6C 4 2.0 19F 4 2.4
1-10   300 89.6   89 98.9   106 91.4   118 84.9   140 92.1   170 89.0   166 91.2   171 86.8   143 87.2
>10 others 35 10.4 others 1 1.1 others 10 8.6 others 21 15.1 others 12 7.9 others 21 11.0 others 16 8.8 others 26 13.2 others 21 12.8
all   335 100.0   90 100.0   116 100.0   139 100.0   152 100.0   191 100.0   182 100.0   197 100.0   164 100.0
Isolates 1992-2006 n= % 2006-2007 n= % 2007-2008 n= % 2008-2009 n= % 2009-2010 n= % 2010-2011 n= % 2011-2012 n= % 2012-2013 n= % 2013-2014 n= %
PenNS   335 5.1   90 5.9   116 5.8   139 6.2   152 6.8   191 7.5   182 8.1   197 8.2   164 7.4
all isolates   6552    1521    2008    2248    2228    2533    2241    2399    2227  
  1. Serotypes 15A, 19A and 23B are depicted in bold for clarity.