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Table 2 Antibiotic resistance profiles for isolates with serotype 23B and serotype 15A

From: Increase of serotypes 15A and 23B in IPD in Germany in the PCV13 vaccination era

  Serotype 15A Serotype 23B
  all MIC range I R MIC 50 MIC 90 all MIC range I R MIC 50 MIC 90
  n= μg/ml % % μg/ml μg/ml n= μg/ml % % μg/ml μg/ml
Penicillin 310 0.015 - 2 47.1 0.3 0.015 0.25 312 0.015 - 0.5 46.5 0.0 0.015 0.25
1992-1993 1 0.015 0.0 0.0 0.015 0.015 0      
1993-1994 0       1 0.015 0.0 0.0 0.015 0.015
1994-1995 2 0.015 0.0 0.0 0.015 0.015 0      
1995-1996 1 0.015 0.0 0.0 0.015 0.015 0      
1996-1997 0       0      
1997-1998 4 0.015 - 0.12 50.0 0.0 0.015 0.12 2 0.015 - 0.06 0.0 0.0 0.015 0.06
1998-1999 5 0.015 - 0.25 20.0 0.0 0.015 0.25 0      
1999-2000 3 0.015 - 0.25 33.3 0.0 0.015 0.25 0      
2000-2001 3 0.015 - 0.12 33.3 0.0 0.03 0.12 0      
2001-2002 9 0.015 0.0 0.0 0.015 0.015 3 0.015 - 0.12 33.3 0.0 0.015 0.12
2002-2003 4 0.015 - 0.25 25.0 0.0 0.015 0.25 1 0.015 0.0 0.0 0.015 0.015
2003-2004 5 0.015 0.0 0.0 0.015 0.015 1 0.25 100.0 0.0 0.25 0.25
2004-2005 4 0.015 - 0.25 25.0 0.0 0.015 0.25 1 0.015 0.0 0.0 0.015 0.015
2005-2006 4 0.015 - 0.06 0.0 0.0 0.015 0.06 1 0.015 0.0 0.0 0.015 0.015
2006-2007 4 0.015 0.0 0.0 0.015 0.015 2 0.015 0.0 0.0 0.015 0.015
2007-2008 5 0.015 - 0.5 40.0 0.0 0.015 0.5 1 0.015 0.0 0.0 0.015 0.015
2008-2009 11 0.015 - 0.5 45.5 0.0 0.015 0.5 11 0.015 - 0.5 45.5 0.0 0.015 0.25
2009-2010 19 0.015 - 1 47.4 0.0 0.03 0.5 22 0.015 - 0.5 59.1 0.0 0.12 0.25
2010-2011 32 0.015 - 0.5 56.3 0.0 0.25 0.25 41 0.015 - 0.5 39.0 0.0 0.015 0.25
2011-2012 51 0.015 - 0.5 52.9 0.0 0.12 0.25 72 0.015 - 0.25 44.4 0.0 0.06 0.25
2012-2013 67 0.015 - 1 61.2 0.0 0.25 0.25 73 0.015 - 0.5 52.1 0.0 0.12 0.25
2013-2014 76 0.015 - 2 50.0 1.3 0.25 0.25 80 0.015 - 0.5 48.8 0.0 0.015 0.25
Cefotaxime 310 0.015 - 1 0.0 0.0 0.015 0.12 312 0.015 - 0.5 0.0 0.0 0.03 0.06
Erythromycin 310 0.06 - 256 0.3 48.7 0.12 256 312 0.06 - 256 0.0 2.9 0.12 0.12
Clindamycin 310 0.06 - 256 0.6 46.5 0.12 128 312 0.06 - 256 0.0 1.0 0.12 0.12
Tetracycline 310 0.12 - 128 0.0 44.8 0.5 64 311 0.03 - 128 0.0 1.6 0.5 0.5
Levofloxacin 284 0.5 - 2 0.0 0.0 1 2 305 0.25 - 8 0.3 0.3 1 1
Chloramphenicol 285 0.5 - 4 0.0 1.1 4 4 307 0.5 - 4 0.0 0.0 4 4
Trimethoprim/Sulfamethoxazole 284 0.12 - 8 5.6 1.8 0.25 0.5 305 0.25 - 8 24.3 18.0 0.25 4
MDR 310    46.8    312    1.3