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Table 1 Effects of PCV7 and PCV13 vaccination on IPD among children (0-15 years) and adults (≥16 years) in Germany

From: Increase of serotypes 15A and 23B in IPD in Germany in the PCV13 vaccination era

Serotype Age group Pre-vaccination (1992-2006) Early vaccination (PCV7) (2007-2010) Late vaccination (PCV13) (2010-2014) Pre-vaccination vs. Early vaccination Early vaccination vs. Late vaccination
n= % n= % n= % p value p value
PCV7 children 1,282 61.8 169 23.5 40 5.2 1,30E-72 4,59E-25
non-PCV7 children 793 38.2 551 76.5 724 94.8   
all children 2,075 100.0 720 100.0 764 100.0   
PCV7 adults 1,943 43.4 1,426 24.7 711 8.2 3.78E-88 5.97E-161
non-PCV7 adults 2,534 56.6 4,338 75.3 7,925 91.8   
all adults 4,477 100.0 5,764 100.0 8,636 100.0   
PCV7 all 3,225 49.2 1,595 24.6 751 8.0 4.39E-189 2.06E-182
non-PCV7 all 3,327 50.8 4,889 75.4 8,649 92.0   
all all 6,552 100.0 6,484 100.0 9,400 100.0   
PCV13 children 1,751 84.4 506 70.3 312 40.8 1.50E-15 1.96E-30
non-PCV13 children 324 15.6 214 29.7 452 59.2   
all children 2,075 100.0 720 100.0 764 100.0   
PCV13 adults 3,238 72.3 3,839 66.6 4,086 47.3 5.24E-10 1.90E-116
non-PCV13 adults 1,239 27.7 1,925 33.4 4,550 52.7   
all adults 4,477 100.0 5,764 100.0 8,636 100.0   
PCV13 all 4,989 76.1 4,345 67.0 4,398 46.8 5.55E-31 9.74E-142
non-PCV13 all 1,563 23.9 2,139 33.0 5,002 53.2   
all all 6,552 100.0 6,484 100.0 9,400 100.0   
23A all 37 0.6 101 1.6 225 2.4 2.45E-08 2.57E-04
23B all 10 0.2 34 0.5 265 2.8 2.26E-04 1.55E-29
23F all 407 6.2 205 3.2 93 1.0 1.36E-16 1.29E-22
15A all 45 0.7 35 0.5 226 2.4 3.13E-01 3.14E-22
15B all 38 0.6 79 1.2 120 1.3 1.22E-04 7.72E-01
15C all 33 0.5 41 0.6 105 1.1 3.52E-01 1.66E-03
15B/C all 71 1.1 120 1.9 225 2.4 1.25E-01 6.55E-01
15F all 6 0.1 1 0.0 4 0.0 3.31E-04 2.31E-02
  1. The pneumococcal season 2006-2007 in which childhood pneumococcal conjugate vaccination was introduced was considered a transition period and left out of the analysis. P-values reaching statistical significance are depicted in bold.