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Table 2 Treatment of documented invasive candidiasis

From: How to treat fungal infections in ICU patients

  First line Alternatives
ESCMID (2012) - Anidulafungin 200 mg loading dose, then 100 mg/day - Liposomal amphotericin B 3 mg/kg
- Caspofungin 70 mg loading dose, then 50 mg/day - Voriconazole 3–6 mg/kg/day
- Micafungin 100 mg - Fluconazole 400–800 mg
- Amphotericin B lipid complex 5 mg/kg
IDSA (2009) Stable patients - Lipid formulations of amphotericin B 3–5 mg/kg daily - Amphotericin B deoxycholate 0.5-1 mg/kg daily
- Fluconazole 800 mg loading dose, then 400 mg
Unstable patients or recent use of fluconazole
- Anidulafungin 200 mg loading dose, then 100 mg/day - Voriconazole 400 mg twice daily for 2 doses, then 200 mg twice daily
- Caspofungin 70 mg loading dose, then 50 mg/day
- Micafungin 100 mg/day