You are viewing the site in preview mode

Skip to main content

Advertisement

Table 5 Mixed effects linear regression analysis of monthly rate of change in the prevalence of each OI (per 1000) adjusted for fixed effects (age, sex and clinic) and random effects (monthly clustering)

From: Trends in prevalence of selected opportunistic infections associated with HIV/AIDS in Uganda

  Cryptococcal meningitis1 Mycobacterium tuberculosis2 Herpes zoster Oral candida3 Genital ulcer
β(95% CI) β (95% CI) β (95% CI) β (95% CI) β (95% CI)
[p-value] [p-value] [p-value] [p-value] [p-value]
Predictor variable (Fixed effect)      
Time* −0.003 (−0.004 to −0.002) [<0.001] −0.023 (−0.023 to −0.022) [<0.001] −0.087 (−0.09 to −0.08) [<0.001] - 0.0296 − 0.0298 to −0.0293) [<0.001] −0.078 (−0.08 to −0.07) [<0.001]
Sex      
  Female 1 1 1 1 1
  Male 0 .0058 (−0.042 to 0.054) [0.813] 0.035 (0.010 to 0.059) [0.004] 0.15 (−0.55 to 0.24) [0.449] −0.008 (−0.021 to 0.004) [0.197] 0.083 (−0.45 to 0.61) [0.758]
Age      
  <30 yrs 1 1 1 1 1
  3039 −0.022 (−0.073 to 0.028) [0.387] −0.021 (−0.046 to 0.004) [0.096] 0.11 (−0.29 to 0.51) [0.588] 0.0002 (−0.012 to 0.013) [0.980] 0.004 (−0.48 to 0.47) [0.986]
  40+ −0.041 (−0.10 to 0.020) [0.187] - 0.035 (−0.066 to −0.003) [0.032] −0.05 (−0.54 to 0.44) [0.841] 0.007 (−0.007 to 0.021) [0.341] 0.49 (−0.11 to 1.09) [0.110]
HIV clinic      
  Tororo 1 1 1 1 1
  Mulago −0.022 (−0.073 to 0.028) [0.387] −0.089 (−0.12 to −0.062) [<0.001] 0.22 (−0.26 to 0.70) [0.373] −0.02 (−0.042 to −0.002) [0.032] 0.25 (−0.84 to 0.34) [0.414]
  Mbarara −0.091 (−0.15 to −0.035) [0.001] −0.12 (−0.15 to −0.088) [<0.001] 0.10 (−0.35to .55) [0.666] −0.020 (−0.038 to −0.002) [0.028] 0.45 (−1.04to 0.13) [0.130]
  Constant 0.77 4.39 14.7 5.3 18.6
  β 0 (0.70 to 0.84) [<0.001] (4.35 to 4.42) [<0.001] (14.0 to 15.5) [<0.001] (5.2 to 5.3) [<0.001] (17.5 to 19.8) [<0.001]
Predictor variable (Random effect)      
Month      
  δ2 μ 0.006 0.001 0.94 0.002 2.8
  (95% CI) (0.0023 to 0.017) (0.0005 to 0.004 (0.39 to2.26) (0.001 to 0.005) (1.2 to 6.5)
  [SE] [0.003] [0.0006] [0.42] [0.001] [1.20]
  δ2 ε 0.041 0.11 0.33 0.060 17.2
  (95% CI) (0.036 to 0.048) (0.10 to 0.11) (7.6 to 9.1) (0.058 to 0.062) (16.0 to 18.5)
  [SE] [0.003] [0.0026] [0.368] [0.001] [0.62]
  1. Key: *Time =144 months, β = beta coefficient, SE = standard error, CI = confidence interval, δ2ε = Residual variance.
  2. δ2μ = random effect monthly variance.
  3. 1Natural log monthly prevalence (per 1000) of Cryptococcal meningitis.
  4. 2Natural log monthly prevalence (per 1000) of Mycobacterium tuberculosis.
  5. 3Natural log monthly prevalence (per 1000) of Oral candida.