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Figure 1 | BMC Infectious Diseases

Figure 1

From: Mass campaigns with antimalarial drugs: a modelling comparison of artemether-lumefantrine and DHA-piperaquine with and without primaquine as tools for malaria control and elimination

Figure 1

Pharmacokinetics and pharmacodynamics of antimalarial drugs are implemented in an agent-based model of malaria transmission and calibrated to clinical data. (A) A simplified model of drug pharmacokinetics uses a double exponential to model antimalarial drug distribution and elimination. (B) Pharmacokinetics of 5 antimalarials as simulated with the simple PK model in a 50 kg adult. (C) Maximum drug concentration with simple PK including age-based dosing, weight-dependent PK parameters, and WHO/CDC age-weight tables. See Tables 1 and 2 for model PK parameters and age-based dose fractions.

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