Pharmacokinetics and pharmacodynamics of antimalarial drugs are implemented in an agent-based model of malaria transmission and calibrated to clinical data. (A) A simplified model of drug pharmacokinetics uses a double exponential to model antimalarial drug distribution and elimination. (B) Pharmacokinetics of 5 antimalarials as simulated with the simple PK model in a 50 kg adult. (C) Maximum drug concentration with simple PK including age-based dosing, weight-dependent PK parameters, and WHO/CDC age-weight tables. See Tables 1 and 2 for model PK parameters and age-based dose fractions.