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Table 1 Analytical sensitivity and specificity showed by the different ELISA and IIF assays used by the participant laboratories

From: International external quality control assessment for the serological diagnosis of dengue infections

  IgM sensitvity IgM specificity IgG sensitivity IgG specificity
Overall* 66.7% (95% CI 62.3%-70.8%) 95.1% (95% CI 92.2%-97.2%) 84.4% (95% CI 80.6%-87.7%) 83% (95% CI 78%-87.1%)
ELISA assays 70.4% (95% CI 65.5%-75%) 97.2% (95% CI 94.4%-98.9%) 83.2% (95% CI 78.5%-87.3%) 83.8% (95% CI 78%-88.7%)
ELISA commercial 75.5% (95% CI 70.3%-80.2%) 97% (95% CI 93.7%-98.9%) 82.4% (95% CI 77.3%-86.8%) 84.5% (95% CI 78.2-89.5%)
Capture assays 82.7% (95% CI 77%-87.4%) 96% (95% CI 91.5%-98.6%) 59.3% (95% CI 45%-72.4%) 97.2% (95% CI 85.4%-99.5%)
Indirect assays 55.6% (95% CI 44%-66.6%) 100% (95% CI 93.3%-100%) 88.9% (95% CI 83.9%-92.9%) 82.6% (95% CI 75.2%-88.5%)
ELISA in house 48.6% (95% CI 35.6%-60.7%) 97.9% (95% CI 88.9%-99.6%) 88.9% (95% CI 73.9%-96.8%) 79.2% (95% CI 57.8%-92.8%)
IIF assays 56.6% (95% CI 46.2%-66.5%) 86.4% (95% CI 75.7%-93.6%) 88.9% (95% CI 81.7%-93.9%) 79.5% (95% CI 68.8%-87.8%)
IIF commercial 59.7% (95% CI 47.5%-71.1%) 97.9% (95% CI 88.9%-99.6%) 88.9% (95% CI 79.9%-94.8%) 77.7% (95% CI 64.4%-87.9%)
IIF in house 48.1% (95% CI 28.7%-68%) 55.5% (95% CI 30.8%-78.4%) 88.9% (95% CI 73.9%-96.8%) 83.3% (95% CI 62.6%-95.2%)
  1. *ELISA, IIF, and rapid test included. Due to the small number of data sets, rapid test were excluded from further analyses.