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Table 3 Analysis of changes in quality of life during the study period

From: Effects of long-term use of macrolides in patients with non-cystic fibrosis bronchiectasis: a meta-analysis of randomized controlled trials

Changes a of SGRQ No. of studies No. of patients Effect size Heterogeneity
Macrolide Control WMD (95%CI) P value I 2 (%) P value
Total 5 213 204 −5.39(−9.88,-0.89) 0.02* 84 <0.001b
Symptoms 3 146 142 −13.38(−30.62,3.86) 0.13 94 <0.001b
Activity 2 87 84 −0.79(−4.67,3.09) 0.69 0 0.71
Impact 2 87 84 −5.88(−9.05,-2.71) <0.001* 36 0.21
  1. Abbreviations: WMD, weighted mean difference. achanges from baseline to the end of the study. bI2 > 50%, a random-effects model was chosen; *It was suggestive of statistical significance.