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Table 2 Analysis of changes in lung function before and after treatment

From: Effects of long-term use of macrolides in patients with non-cystic fibrosis bronchiectasis: a meta-analysis of randomized controlled trials

Changes a No. of studies No. of patients Effect size Heterogeneity
Macrolide Control WMD (95%CI) P value I 2 (%) P value
FEV1(L) 4 109 105 0.02(0–0.04) 0.02* 2 0.38
FEV1,% predicted 3 115 110 1.52(0.49-2.56) 0.004* 0 0.57
FVC(L) 3 98 95 0.05(−0.03-0.13) 0.25 54 0.11
  1. Abbreviations: WMD, weighted mean difference; 95%CI, 95% confidence interval; FEV1, forced expiratory volume in the first second; FVC, forced vital capacity. achange from baseline to the end of the study; * It was suggestive of statistical significance.